摘要
目的探讨支气管哮喘反复呼吸道感染患儿进行补锌治疗的临床实效性评价,为临床治疗提供参考依据。方法选取医院2012年1月-2013年1月76例支气管哮喘反复呼吸道感染患儿,将其分为观察组与对照组,各38例,对照组患儿给予雾化吸入布地奈德治疗,观察组患儿给予口服甘草锌颗粒+雾化吸入布地奈德进行治疗,观察两组患儿治疗后呼吸道感染次数、哮喘发作天数及抗菌药物使用等临床指标及血清免疫球蛋白浓度,数据采用SPSS 17.0软件进行统计分析。结果两组患儿经过治疗后,观察组患儿的呼吸道感染次数、哮喘发作天数及抗菌药物使用天数均低于对照组,两组比较差异有统计学意义(P<0.05);观察组及对照组患儿IgA、IgG治疗后与治疗前浓度比较,差异均有统计学意义(P<0.05),IgM对比分析后,差异无统计学意义。结论支气管哮喘合并反复呼吸道感染患儿一旦锌含量偏低时,需给予补锌进行治疗,疗效显著。
OBJECTIVE To observe the clinical effectiveness of bronchial asthma with recurrent respiratory tract in‐fections by zinc therapy in children so as to provide references for clinical treatments .METHODS Totally 76 cases of children with bronchial asthma combined with recurrent respiratory tract infections from Jan .2012 to Jan .2013 were selected in our hospital ,and they were divided into control group and observation group with 38 patients re‐spectively .The control group was treated with nebulized budesonide and the control group on the basis of this , was treated with oral licorzine granules .Times of respiratory tract infections ,days of asthma attack ,the antibiotic use and serum IgG concentration were observed .SPSS 17 .0 was adopted for statistical analysis .RESULTS After treatments ,the times of respiratory tract infections ,days of asthma attack and days of antibiotic use in the obser‐vation group were significantly lower than those of the control group （P〈0 .05） .Concentration of IgA and IgG before and after the treatments compared in the two groups were significantly different （P〈0 .05） .IgM levels be‐fore and after the treatments between the two groups were not significant （P〈0 .05） .CONCLUSION Children with bronchial asthma combined with recurrent respiratory tract infections need to take a routine test of zinc level . When the level of zinc is low ,they should be treated with zinc right away .
出处
《中华医院感染学杂志》
CAS
CSCD
北大核心
2015年第16期3819-3820,3823,共3页
Chinese Journal of Nosocomiology
基金
浙江省卫生适宜技术成果转化计划基金资助项目(2011ZHB012)
关键词
支气管哮喘
反复呼吸道感染
补锌
Bronchial asthma
Recurrent respiratory tract infections
Zinc treatment
