摘要
k-ras作为一种原癌基因,在调控细胞增殖方面起着重要作用。k-ras基因被多种因素激活后,可产生一系列生物学效应,导致多种肿瘤的发生与演进。k-ras异常激活还可影响肿瘤分子靶向治疗的疗效。本文对肿瘤中k-ras基因的激活机制异常激活及其对临床药物疗效的影响作一综述。
k -ras,which was known as an important proto -oncogene,plays an important role in cell proliferation. The active k -ras could lead series of biological effects,which can cause the progression of cancer.Activated k -ras also has influence on the targeted therapy of cancer.The active mechanism of k -ras and how does it affect clinical medication were summarized.
出处
《现代肿瘤医学》
CAS
2015年第18期2698-2701,共4页
Journal of Modern Oncology
