摘要
目的应用Meta分析的方法评估转录因子7类似物-2（TCF7L2）基因单核苷酸多态性与妊娠期糖尿病（GDM）相关性。方法计算机检索PubMed、Science Direct、CNKI、万方、维普等数据库,全面收集2014年10月以前发表的有关TCF7L2基因单核苷酸多态性与GDM关系的国内外文献;严格制定纳入/排除标准,采用Newcastle-Ottawa Scale（NOS）标准进行质量评估后,使用Q检验和I2统计量进行异质性检验,并进行数据合并,再以RevMan 5.1和Stata 12.0软件对符合质量要求的文献进行Meta分析。结果 （1）共纳入符合标准的8篇病例对照研究文献,包括2650例患者和3514例对照。（2）等位基因T/C的Meta分析OR=1.29,95%CI为1.08~1.63;TT/TC基因型与CC基因型比较的Meta分析OR=1.37,95%CI为1.21~1.78。（3）Egger线性回归法：TT基因型相对于CT＋CC基因型t=-2.74,P=0.51,95%CI为-11.9~6.42;CC基因型相对于CT＋TT基因型t=2.93,P=0.64,95%CI为-3.07~8.96。结论 TCF7L2基因单核苷酸多态性与GDM的发生相关,携带TT/CT基因型的孕妇发生GDM的风险升高。
Objective To evaluate the correlation between single nucleotide polymorphism of gene transcription factor 7 analogue-2 （TCF7L2） and gestational diabetes mellitus （GDM） by Meta analysis.Methods Reference about the correlation between gene TCF7L2 and GDM published before Oct,2014 were collected by searching PubMed,Science Direct,CNKI,WanFang and WeiPu database.Strict inclusion and exclusion criteria were made. The references’ qualities were valuated with Newcastle-Ottawa Scale （NOS）,heterogeneity tested with Q-test and I2 statistic,and then date merged.Meta analysis of the references which meet quality requirements was made with Newman 5.1 and Stata 12.0 software. Results （1）8 references about case-control studies meeting the inclusion criteria were adopted. 2650 cases and 3514 controls were included in the 8 references.（2）Meta analysis of alleles T/C：OR=1.29,95%ofCI was 1.08-1.63;Meta analysis of comparison between genotype TT/TC and genotype CC：OR=1.37,95% ofCI was 1.21-1.78.（3）Egger liner regression method：genotype TT relative to genotype CT＋CC：t=-2.74,P=0.51,95% ofCI was -11.9-6.42;genotype CC relative to genotype CT＋TT：t=2.93,P=0.64,95% of CI was -3.07-8.96.Conclusion Single nucleotide polymorphism of TCF7L2 is related to the occurrence of GDM. Pregnant woman carrying genotype TT/CT has higher occurrence rate of GDM.
出处
《中国医药科学》
2015年第7期183-185,197,共4页
China Medicine And Pharmacy
基金
广东省深圳市卫生计生系统科研项目(201402066)
