摘要
目的：探讨 EV71病毒引起手足口病患儿免疫状态变化。方法收集2013年6月～2014年12月我院收治的手足口病患儿120例，按照病情程度分为轻症组、重症组各60例，收集同期来我院进行健康体检的正常健康体检儿童60例作为对照组，测定三组 IL-10水平、体液免疫功能及细胞免疫。结果轻症组、重症组 IgM、IL-10水平均高于对照组，重症组 IgG、IgA、IgM、IL-10水平高于轻症组（P ＜0.05）。轻症组、重症组 CD16＋56＋、CD23＋、CD19＋高于对照组，CD25＋低于对照组（P ＜0.05），重症组 CD19＋高于轻症组，CD16＋56＋、CD25＋低于轻症组（P ＜0.05）；重症组 CD4＋、CD8＋低于轻症组及对照组（P ＜0.05）。结论EV71病毒引起的 HFMD 患儿存在细胞免疫、体液免疫功能紊乱，疾病程度越严重，细胞免疫、体液免疫功能紊乱程度越严重，应提高重视，及时检测，提高患儿的预后，降低死亡率。
Objective To investigate the cause of EV71 HFMD child immunization status changes. Methods 120 cases with hand, foot and mouth disease were selected from June 2013 to December 2014 in our hospital, according to severity they were divided into the mild group（n=60）, the severe group（n=60）, 60 cases of children were collected came to our hospital for normal healthy physical examination as the same period as the mild group and the severe group and considered them as the control group. IL-10 level, humoral and cellular immune function of three groups were measured. Results IgM, IL-10 levels of the mild group, severe group were higher than the control group, IgG, IgA, IgM, IL-10 levels of the severe group was higher than mild group （P 〈 0.05）. CD16＋ 56＋, CD23＋, CD19＋ of Mild group, severe group was higher than the control group, CD25＋ of the Mild group, severe group was lower than the control group （P 〈 0.05）, CD19＋ of the severe group was higher than the mild group, CD16＋56＋,CD25＋ was lower than the mild group （P 〈 0.05）; CD4＋, CD8＋ of the severe group was lower than the mild group and the control group （P 〈 0.05）. Conclusion Children with HFMD caused by EV71 virus exists cellular immunity, humoral immune dysfunction, the more severe the disease extent, cell-mediated immunity, humoral immune dysfunction more serious degree, should increase attention to timely detect and improve the prognosis of children and reduce mortality.
出处
《中国医药科学》
2015年第9期49-51,共3页
China Medicine And Pharmacy
基金
广东省深圳市卫生和人口计生委员会医疗卫生类科研项目(201302164)
