摘要
目的：探讨在老年舒张性心力衰竭诊治中采用 C 反应蛋白与 N 末端脑利钠肽原的作用。方法选取2013年3月～2014年5月本院就诊的老年舒张性心衰患者60例，按舒张性心衰的分级分为弛缓受损组、假性正常化充盈组、限制性充盈组3组。选取同期健康体检老人25例为对照组。观察患者的 N 末端脑利钠肽原和 C 反应蛋白的变化。结果治疗前 DHF 亚组的 NT-ProBNP 和 CRP 水平明显高于对照组，差异有统计学意义（均 P ＜0.05）。弛缓受损组，假性正常化充盈组及限制性充盈组的 NT-ProBNP 和 CRP 水平随舒张功能不全程度加重而升高，限制性充盈组明显高于其他两组，差异有统计学意义（均 P ＜0.05）。老年 DHF 不同分期组治疗后 NT-ProBNP 和 CRP 水平皆显著下降，与治疗前比较，差异有统计学意义（均P ＜0.05）。结论在老年 DHF 患者中，血浆 NT-ProBNP 和 CRP 升高明显，其升高幅度与舒张功能不全程度成正比。
Objective To study the effect of C reactive protein and N-terminal pro-brain natriuretic peptide（NT-proBNP） in the treatment of senile diastolic heart failure. Methods 60 patients with senile diastolic heart failure, who were treated in our hospital from March 2013 to May 2014, were selected and divided into impaired chalasia group, false normalization filling group,restrictive filling group according to the grade of diastolic heart failure, while 25 contemporaneous cases of elderly people with health examination who were selected as the control group. To observe the change of C reactive protein and NT-proBNP. Results NT-ProBNP and CRP level before treatment in DHF subgroup were higher than which in control group, the differences were statistical significance（P 〈 0.05）. NT-ProBNP and CRP level in impaired chalasia group, in false normalization filling group, and in restrictive filling group had enhanced along with the aggravation of the degree of diastolic dysfunction, while which in restrictive filling group was obviously higher than which in the other two groups, the differences were statistical significance（P 〈 0.05）. NT-ProBNP and CRP level after treatment at different stage of senile DHF group has obviously declined than which before treatment, the differences were statistical significance（P 〈 0.05）. Conclusion Plasmatic NT-ProBNP and CRP level of senile DHF patients has obviously raised, with the increased extent proportional to the degree of diastolic dysfunction.
出处
《中国医药科学》
2015年第9期127-129,共3页
China Medicine And Pharmacy
