摘要
目的：对比帕利哌酮缓释片与阿立哌唑口腔崩解片治疗精神分裂症的疗效及安全性。方法：将符合入组标准的69例精神分裂症患者随机分为帕利哌酮缓释片组（研究组）35例及阿立哌唑口腔崩解片组（对照组）34例，在治疗前及第4、8周末，用阳性和阴性症状量表（PANSS）评定疗效，用副反应量表（TESS）评定不良反应。结果：共完成62例，研究组32例，对照组30例。治疗8周末，研究组有效率93．8％，对照组有效率90．0％，2组比较差异无统计学意义（X2=0．29，P：0．667）。2组在治疗第4、8周末时PANSS总分及阳性症状、阴性症状、精神病性症状评分较治疗前均减少（Ps〈0．05）。在治疗4周末时，研究组阴性症状分下降较对照组明显（t=2．20，P=0．032）；治疗8周末时，研究组阴性症状分下降也较对照组明显（t=2．08，P=0．042），2组不良反应发生率差异无统计学意义（】【2=1．00，P=0．316）。结论：帕利哌酮缓释片和阿立哌唑口腔崩解片对精神分裂症疗效相当，且帕利哌酮缓释片对阴性症状有较好的疗效。
Objective： To study the efficacy and safety in the treatment of schizophrenia between Paliporidone extended - release tablets and aripiprazole orally disintegrating tablets. Methods： There were 69 eases of schizophrenia patients who accord with the criteria, they were randomized to study group which 35 eases of paliperidone extended - release tablets and control group which 34 cases of aripi- prazole orally disintegrating tablets. Among the pre - treatment,the medication four weeks and eight weeks, the efficacy was evaluated with positive and negative syndrome scale （PANSS）, adverse reaction was assessed by Treatment Emergent Symptom Scale（TESS）. Results： A total of 62 cases completed which the 32 cases study group and the 30 cases control group. After 8 weeks of treatment, study group effi- cacy was 93.8%, the control group efficacy was 90.0%, the difference was not statistically significant （ X2 = 0.29, P = 0.667）. After the medication four weeks and eight weeks , the PANSS scores, positive symptoms scores,negative symptoms scores, psychotic symptoms scores were reduced which compared with pre - treatment（ Ps 〈 0.05 =. After the medication four weeks and eight weeks, negative symp- toms scores from the study group decreased more significantly than the control group respectively （t = 2.20, P = 0. 032） （t = 2.08, P = 0.042 ）, adverse reaction was no significant difference from two groups （ x2 = 1.00,P =0.316）. Conclusion： The efficacy of Paliper- idone extended - release tablets and aripiprazole orally disintegrating tablets for Schizophrenia was fairly, and Paliporidone extended - release tablets to negative symptoms have better effect.
出处
《中国伤残医学》
2015年第17期28-30,共3页
Chinese Journal of Trauma and Disability Medicine
关键词
帕利哌酮缓释片
阿立哌唑口腔崩解片
精神分裂症
Paliperidone extended - release tablets
Aripiprazole orally disintegrating tablets
Schizophrenia
