摘要
目的探讨伴有t(8;21)急性髓细胞白血病(朋Ⅲ。)的细胞形态学及细胞遗传学特点及关系。方法 63例成人t(8;21)AML患者分为单纯"8;21)组(24例)、t(8;21)伴陛染色体丢失组(27例)和t(8;21)伴其他异常染色体组(12例),分析染色体核型与FAB分型的关系。结果按FAB分型,M2型49例(77.8%),M1型4例(6.34%),M4型7例(11.11%),M0型2例(3.2%),M5型1例(1.6%)。t(8;21)伴陛染色体丢失27例,其中—Y男性患者19例,—x女性患者8例。其他附加染色体异常改变12例,其中9q-3例、+4、+8、-7/7q-者各有2例。K8;21)伴其他异常染色体组中M0、M1、M4、M5病例的分布多于单纯t(8;21)组,差异有统计学意义(Z=3.941,P=0.02),也多于"8;21)伴性染色体丢失组,差异有统计学意义(矿-9.716,P=0.004);t(8;21)伴性染色体丢失组中M0、M1、M4、M5病例的分布与单纯"8;21)组比较差异无统计学意义(矿=0.028,尸=0.867)。结论单纯t(8;21)及t(8;21)伴性染色体丢失主要见于AML-M2,而t(8;21)伴其他异常染色体异常更易见于M0、M1、M4、M5型的AML。
Objective To investigate the cytogenetic and morphological features of the patients with acute myeloid leukemia （AML） with t（8; 21） and their relativity. Methods The 63 adult cases with AML from department of hematology were divided into three groups： simple t（8; 21） group （n = 24）, t（8; 21） with deletion of sex chromosomes （n=27） and t（8; 21） with other abnormal chromosome group （n=12）. The relationship between the chromosome karyotype and lab type were analyzed among groups. Results According to FAB classification, 49 cases （77.8%） were M2 type, 4 cases M1 type （6.34%）, 7 cases M4 type （11.11%）, 2 cases, M0 type（3.2%）, 1 cases M2 type （1.6%）. t（8; 21） with sex chromosome loss in 27 cases, among which 19 cases of male patients with -X, 8 cases of female patients with -Y. Other chromosome abnormalities were changed in 12 patients, including 9q-in 3 patients, ＋4, ＋8, and -7/7q-in 2 patients respectively. The number of cases （M0, M1, M4, M5 ） in the group t（8; 21） with other chromosomal abnormalities is higher than those in the simple t（8; 21） group with significant difference （χ^2=3.941, P = 0.02）, also higher than those in t（8; 21） chromosomes deletion sex group with significant difference （χ^2=9.716, P = 0.004）. The number of cases （M0, M1, M4 and M5） in t（8; 21） with sex chromosome loss group did not exhibit significant difference compared with simple t（8; 21） group. （χ^2=0.028, P=0.867）. Conclusion t（8; 21） alone and t（8; 21） with deletion of sex chromosomes mainly appeared in ALM-M2. t（8; 21） with other additional chromosomal abnormalitfes were more common in M0, M1, M4 and M5.
出处
《兰州大学学报（医学版）》
CAS
2015年第4期36-39,共4页
Journal of Lanzhou University（Medical Sciences）
基金
兰州市科技局科技发展项目(2013-3-24)
