摘要
目的探讨匹多莫德口服液联合0.025%维A酸乳膏治疗儿童面部顽固性扁平疣的疗效及对机体免疫功能的影响。方法 120例扁平疣患儿随机分为两组,试验组患儿(60例)给予匹多莫德口服液,隔日晚睡前外用0.025%维A酸乳膏,对照组患儿(60例)给予左旋咪唑口服,0.025%维A酸乳膏外用同试验组。4周为1个疗程,治疗2个疗程。治疗前后检测患儿血清免疫球蛋白(IgG、IgA、IgM),T淋巴细胞亚群(CD3+、CD4+、CD8+),随访1个月。结果试验组患儿痊愈率为73.3%,有效率为91.7%;对照组患儿痊愈率为46.7%,有效率为66.7%,试验组痊愈率和有效率明显优于对照组;试验组的起效时间和痊愈时间均早于对照组;试验组患儿治疗后T淋巴细胞亚群和免疫球蛋白水平均较治疗前明显升高,与对照组治疗后比较也明显升高,差异均有统计学意义。结论匹多莫德口服液联合0.025%维A酸乳膏治疗儿童面部顽固性扁平疣疗效好,安全性较高,可显著增强患儿细胞免疫及体液免疫功能。
Objective To observe the efifcacy of pidotimod combined with 0.025% tretinoin cream in treatment of children with severe verruca plana on face and host’s immune function changes. Methods Total 120 cases were enrolled, randomly divided into two groups, test group （60 cases） were treated with pidotimod and 0.025% tretinoin cream, and the control group （60 cases） were treated with oral levamisole and 0.025%tretinoin cream topically. Treatment duration included two courses, and each course lasted for 4 weeks, serum immunoglobulin （IgG, IgA, IgM） and T lymphocyte subsets （CD3＋, CD4＋, CD8＋） were tested before and after the treatment. Results The cure rate and the total effective rate were 73.3%and 91.7%in test group, 46.7%and 66.7%in control group. In test group, levels of serum immunoglobulin （IgG, IgA, IgM） and T lymphocyte subsets （CD3＋, CD4＋, CD8＋） were higher than before the treatment and control group, all the differences were signiifcant. Conclusion Oral pidotimod combined with 0.025%tretinoin cream topically used in treatment of children with severe verruca plana on face is effective, safe, which may improve the host’s immune function signiifcantly.
出处
《实用皮肤病学杂志》
2015年第4期266-269,共4页
Journal of Practical Dermatology
关键词
扁平疣
儿童
匹多莫德
维A酸
免疫球蛋白
T细胞亚群
Verruca plana
Children
Pidotimod
Tretinoin
Immunoglobulin
T lymphocyte subsets
