摘要
目的探讨胰岛素样生长因子-1(IGF-1)在儿童性早熟中的诊断价值。方法收集特发性中枢性性早熟(ICPP)组101例、单纯性乳房早发育(SPT)组96例,同时收集青春发育前健康女童85例为对照组。用化学发光法检测ICPP组、SPT组及对照组的IGF-1和LH峰值水平。结果 ICPP组血清IGF-1水平[(361.26±108.55)ng/m1]明显高于SPT组[(232.62±81.14)ng/m1]和对照组[(221.44±88.91)ng/m1],差异有统计学意义(P<0.05);SPT组IGF-1水平与对照组比较,差异无统计学意义(P>0.05);ICPP组IGF-1水平与LH峰值呈显著正相关(r2=0.6181,P<0.01);IGF-1>298.58ng/ml对诊断ICPP的灵敏度、特异度、阳性预测值分别为94.6%、96.0%、95.1%。结论 IGF-1水平的测定可作为ICPP诊断的参考指标,对ICPP和SPT有鉴别诊断意义。
Objective To discuss the diagnostic value of the insulin-like growth factor-1（IGF-1） in children precocious puberty. Methods A total of 101 girls with idiopathic central precocious puberty（ICPP）, 96 girls with simple premature thelarche（SPT） were collected as case groups, and 85 healthy girls in prepuberty were collected as the control group. The level of IGF-1and the peak of luteinizing hormone（LH） in the serum of all the enrolled subjects were detected by using Chemiluminescence.Results The level of IGF-1 in ICPP groups were 361.26±108.55ng/ml, obviously higher than that in SPT groups（232.62±81.14ng/ml） and in controls groups（221.44±88.91ng/ml）.The difference above was statistically significant（P〈0.05）, there was no significantly difference in the levels of IGF-1between SPT group and controls group（P〉0.05）; the levels of IGF-1 have a remarkable positive correlation with the peak of LH（r2=0.6181,P〈0.01）; the IGF-1〉298.58ng/ml has the degree of sensitivity（94.6%）, specific（96.0%） and positive predictive value（95.1%） for the diagnosis of ICPP. Conclusion The serum concentrate of IGF-1 has a value of reference index in the diagnosis of ICPP and a significance in distinguishing between ICPP and SPT.
出处
《实验与检验医学》
CAS
2015年第4期427-429,共3页
Experimental and Laboratory Medicine
