摘要
目的探讨长托宁和氯解磷定救治有机磷农药中毒的应用。方法选择口服途径中毒、年龄>14岁、无肝肾疾患和应用抗毒剂史的住院患者56例,根据中毒表现及胆碱酯酶(CHE)变化调整药物用量和间隔时间。结果用药总量和次数随病情加重而增多,达到长托宁化时间:轻度为(25±8)min,中度为(78±17)min,重度为(186±54)min。CHE在治疗后1 h与治疗前比较差异有统计学意义(P<0.01)。结论用药过程可分为首次、二次、重复和维持四个阶段,不可机械地定时定量。足量指标是长托宁化和CHE>50%。评估、用药、再评估是防止用药不足或过量的重要措施。
Objective To explore the penehyclidine hydrochloride and pralidoxime chloride treatment application methods of organophosphorus pesticide poisoning. Methods A total of 56 cases of hospitalized with oral route poisoning were selected in the study, aged more than 14 years old, without liver or kidney diseases and was not treated with counterpoison before hospitalization. The dose and time interval of medication was adjusted base on the clinical manifestations and the cholinesterase measurements. Results As the degree of poisoning aggravating, the total dosage and frequency of counterpoison increased. The time of achievement of atropinization was（25±8） min in mild intoxication patients,（78±17） minutes in moderate intoxication patients, and（186±54） min in severe intoxication patients. At one hour after treatment, the cholinesterase measurements was significant different compared with before the treatment（P〈0.01 ）. Conclusion The process of drug treatment can be divided into four stages, the first, second, repetition and maintain. Can not be given drugs with the fixed time and fixed quantity. Atropinization and cholinesterase measurements over 50% were two important index of full dose. Assessment, medication, and reassess were an important measure to prevent inadequate or excessive medication.
出处
《中国现代医生》
2015年第22期80-82,85,共4页
China Modern Doctor
关键词
长托宁
氯解磷定
有机磷农药中毒
胆碱酯酶
Penehyclidine hydrochloride
Pralidoxime chloride
Organophosphorus pesticide poisoning
Cholinesterase measurements
