摘要
目的探讨结核感染T细胞检测(T-SPOT)在早期结核性脑膜炎与隐球菌性脑膜炎鉴别诊断中的价值。方法结核性脑膜炎组患者、隐球菌性脑膜炎组患者在入院1周内进行结核菌素试验(PPD)、结核抗体、血清腺苷脱氨酶(ANA)及T-SPOT检测。结果 PPD、结核抗体、ANA及T-SPOT检测在结核性脑膜炎患者入院1周检查阳性率分别为75%、25%、50%、100%。PPD、结核抗体、ANA及T-SPOT检测在隐球菌性脑膜炎患者入院1周检查阳性率分别为50%、12.5%、25%、25%。T-SPOT比PPD、结核抗体、ANA在结核性脑膜炎组中阳性率较高,组间阳性率差别有统计学意义(P<0.05)。结论 T-SPOT检测可作为早期鉴别结核性脑膜炎和隐球菌性脑膜炎的辅助方法,但应先排除颅外结核感染。
Objective To evaluate value of the T-SPOT test for early differential diagnosis of cryptococcal meningitis and tubercular meningitis. Methods PPD, tuberculosis antibody, ANA and T-SPOT test were used in cryptococcal meningitis group patient, tubercular meningitis group patient. Results The positive incidence of PPD, tuberculosis antibody, ANA and T-SPOT test in tubercular meningitis were 75%, 25%, 50% and 100% respectively. The positive incidence of PPD, tubercu losis antibody, ANA and T SPOT test in cryptococcal meningitis were 50%, 12.5%, 25% and 25% respectively. The positive incidence of TSPOT test in tubercular meningitis was higher than PPD, tuberculosis antibody and ANA, and the difference was statistically significant between cryptococcal meningitis group and tubercular meningitis group （P〈0.05）. Conclusion T SPOT test is a supporting method for early differential diagnosis of cryptococcal meningitis and tubercular meningitis, excluding intracranial tuberculosis infection firstly.
出处
《福建医药杂志》
CAS
2015年第4期114-116,共3页
Fujian Medical Journal
基金
福建省卫生厅青年科研基金(2012-1-46)
关键词
结核感染T细胞检测
T-SPOT
结核性脑膜炎
隐球菌性脑膜炎
鉴别诊断
enzyme-linked immunosorbent assay of T lymphocytes~ T SPOT~ tubercular meningitis
cryptoeoccal meningitis
differential diagnosis
