摘要
目的探讨肝功能指标及慢性肝炎病毒感染状态对肝脏摄取18F-FDG的影响。方法回顾性分析713名（男504名，女209名，年龄24—74岁）体格检查者的18F．FDGPET／CT检查、肝功能及肝炎病毒检验资料，测量肝右叶SUVmax，通过两样本t检验比较HBsAg及HCV抗体阴性、阳性组间SUVmax。的差异，通过相关分析、偏相关分析和多元线性回归分析探讨肝功能指标与SUVmax。间相关性。结果受检者的肝脏SUVmean。为1．86±0．38。受检者中，449名有HBsAg检测结果，其中65名（14．5％）阳性，384名（85．5％）阴性；477名有HCV抗体检测结果，其中53名（11．1％）阳性，424名（88．9％）阴性。HBsAg及HCV抗体阴性、阳性组间SUVmean。差异无统计学意义（t=1．042和1．283，均P〉0．05）。结合胆红素、球蛋白、AST与SUVmax。显著相关（偏相关r＇=0．191、-0．087和0．132，均P〈0．05），是预测肝脏18F—FDG摄取变化的独立因素，其中球蛋白的预测能力最大（标准化β′=0．112，P〈0．05）。结论肝脏摄取18F-FDG受某些肝功能指标影响，结合胆红素、球蛋白及AST是预测肝脏18F—FDG摄取变化的独立因素。对肝脏代谢活性的评估需结合肝功能检验结果。
Objective To identify impacts of infection status of chronic hepatitis viruses and bio- chemical parameters of liver function on hepatic FDG uptake. Methods The results of 18F-FDG PET/CT, liver function biochemical tests and hepatic virus tests of 713 healthy adults （504 males, 209 females, age 24-74 years） were retrospectively analyzed. Two-sample t test, correlation analysis, partial correlation analysis and muhiple linear regression were performed to identify correlations of liver SUV with the biochemi- cal parameters and hepatic viral infection status. Results HBsAg tests were performed in 449 subjects, with the results of 65 （14.5%） positive and 384 （85.5%） negative. HCV antibody tests were performed in 477 subjects, with 53 （11.1% ） positive and 424 （88.9%） negative. The average SUVmean of the total sub- jects was 1.86±0.38. There was no significant difference of SUV between HBsAg positive group and nega- tive group （t= 1. 042, P〉0.05）, or between HCV antibody positive group and negative group （t= 1. 283, P〉 O. 05 ）. Serum conjugated bilirubin, globulin and AST were significantly correlated with liver SUVmean（r＇ =-0.191, -0.087 and 0.132, all P〈0.05）. These parameters were independent variables on predicting variance of liv- er SUV with globulin showing the largest predicting value （standardized β＇=-0.112, P〈0.05 ）. Con- clusions Functional status of liver may affect liver 18F-FDG uptake. Serum conjugated bilirubin, globulin and AST may be the independent variables on predicting variance of liver SUV . Liver functional test re- suits should be taken into consideration when hepatic 18F-FDG uptake is interpreted.
出处
《中华核医学与分子影像杂志》
北大核心
2015年第4期254-257,共4页
Chinese Journal of Nuclear Medicine and Molecular Imaging
