摘要
结直肠癌的分子靶向治疗虽然已经取得确切的临床疗效,但并非所有患者都能从中获益。表皮生长因子受体通路的各靶点基因突变,可能是影响其作用发挥的重要因素。此外,选择不同的化疗药物与其联合应用,也会在一定程度上影响其疗效的发挥。因此,本文就可能影响靶向药物疗效的原因做一系统性综述。
The effects of molecular target therapy on colorectal cancer are definite,but not all the patients diagnosed with colorectal cancer could benefit from it. The failed therapy could be related to point mutations of various genes in epidermal growth factor receptor pathway. Besides,the effects of molecular target therapy could be influenced by the combined chemical medicine as well. Therefore the aim of this article was to conduct a systematic review to explore all the possible causes that influence the effects of molecular target therapy.
出处
《中国临床药理学杂志》
CAS
CSCD
北大核心
2015年第16期1681-1683,共3页
The Chinese Journal of Clinical Pharmacology
关键词
表皮生长因子受体
肠肿瘤
药物疗法
epidermal growth factor receptor
intestinal tumor
drug treatment
