摘要
目的探讨妊娠期高血压患者新生儿脐静脉血管内皮炎性因子水平对妊娠结局的影响。方法选取行剖宫产手术的妊娠期高血压患者30例,另取同期正常妊娠行剖宫产手术患者30例,分别测量各组新生儿脐静脉血浆中的一氧化氮(NO)、内皮素(ET)以及血清单核细胞趋化蛋白-1水平(MCP-1)水平,并观察新生儿结局,分析新生儿脐静脉血管内皮炎性因子水平与妊娠结局相关性。结果妊娠期高血压组较正常妊娠对照组新生儿脐静脉血NO水平降低,差异有统计学意义(P<0.05);MCP-1和ET较正常妊娠对照组明显升高,差异有统计学意义(P<0.05);新生儿宫内窘迫和死亡的发生率明显升高,新生儿Apgar评分明显降低,差异有统计学意义(P<0.05)。结论妊娠期高血压患者新生儿脐静脉血NO水平降低,ET、MCP-1水平升高,可能是新生儿宫内窘迫和死亡、新生儿评分低的一个原因。
Objective To explore the influence on pregnancy outcome of neonatal umbilical vein endothelial inflamma- tory factor levels for patients with gestational hypertension. Methods A total of 30 mothers in our hospital were chosen. These mothers were gestational hypertension patients which will be terminated the line caesarean delivery. Another 30 cases during the same period of normal pregnancy cesarean section patients, the levels of NO; ET, MCP-1 and neonatal outcome were comparative analyzed. Neonatal umbilical vein endothelial inflammatory factor levels and preg- nancy outcome were compared. Results The difference of NO levels was statistically significant between gestational hy- pertension group and normal pregnancy group （P〈0.05）; The level of ET and M CP-1 in gestational hypertension group were higher than normal pregnancy group, the difference was statistically significant（P〈0.05）. Higher incidence of neonatal intrauterine distress and death, neonatal score was low, the difference was statistically significant（P〈0.05）. Conclusion This is a possible factor that lower umbilical blood levels of NO, higher levels of ET and MCP-1 of gesta- tional hypertension, which leading to fetal distress and neonatal mortality, neonatal score low.
出处
《中国现代医生》
2015年第24期17-20,共4页
China Modern Doctor
基金
浙江省宁波市自然科学基金项目(2013A610220)
关键词
妊娠期高血压
血管内皮炎性因子
妊娠结局
新生儿
Gestational hypertension
Endothelial inflammatory factors
Pregnancy outcoines
Newborns
