摘要
目的以单面中刻痕的缬沙坦片为例对刻痕片进行药学研究。方法对缬沙坦刻痕片分割的方法及损失量进行考察,并研究分割后的释放行为和脆碎度。结果单面中刻痕的缬沙坦片利于分割,且分割后损失量<0.16%,单半片释放行为与整片相似,脆碎度考察后能符合药典要求。结论单面中刻痕的缬沙坦片可以被均匀的分割,能正常释放,有利于临床的剂量调整。
OBJECTIVE Pharmaceutical investigate for the scoring study based on valsartan tablets which were scored on one side. METHODS Tablets splitting method of inspecting and loss of mass test, dissolution curve and friability test for segmentation were researched. RESULTS Valsartan tablets scored on one side could be splitted easily, the loss of mass was less than 0.16%. Dissolution curve of segmentation was smilar with the whole tablet. Result of friability could be met the criterion of Ch.E CONCLUSION Tablet segments of valsartan tablets which scored on one side can be spiltted uniformly and released normally. The score benefits the clinical dose adjustments.
出处
《中国现代应用药学》
CAS
CSCD
2015年第8期955-957,共3页
Chinese Journal of Modern Applied Pharmacy
关键词
缬沙坦片
分割性试验
刻痕研究
valsartan tablets
splitting test
scoring study
