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电解质对新生儿肠外营养液稳定性的影响 被引量:13

Effects of Electrolyte on the Stability of Neonatal Parenteral Nutrition
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摘要 目的:研究几种常见电解质对新生儿肠外营养液稳定性的影响。方法:室温(25℃)下考察仅含一价或二价离子的电解质(10%氯化钠注射液、10%氯化钾注射液、25%硫酸镁注射液、葡萄糖酸钙注射液)的营养液和同时含一价、二价离子的电解质的营养液混合放置24 h内的外观变化,测定其p H和不溶性微粒数、乳粒粒径大小及粒度分布(多分散指数,PDI)。结果:加入电解质的营养液的p H均大于5,均符合质量要求;外观均未出现沉淀、絮凝、变色等现象;仅含一价离子的电解质的营养液放置24 h出现少量挂壁现象,但未出现破乳现象;仅含二价离子的电解质的营养液放置24 h出现少量挂壁现象,且出现破乳现象;同时含一价和二价离子的电解质营养液放置12 h出现少量挂壁现象,放置24 h挂壁现象更明显且出现微量破乳现象,同时出现粒径大于5μm的乳粒和粒径大于25μm的不溶性微粒,且平均粒径和PDI值均比前2种情况更高(P<0.05)。结论:新生儿肠外营养液中含一价和二价离子的电解质,特别是含二价离子的电解质加入越多,其稳定性越差,表现为乳粒粒径增大、不溶性微粒数增加。 OBJECTIVE:To study the effects of electrolyte on the stability of the neonatal parenteral nutrition. METHODS:Under room temperature(25 ℃),the neonatal parenteral nutrition containing only monovalent or bivalent ion electrolyte(10% Sodium chloride injection,10% Potassium chloride injection,25% Magnesium sulfate injection,and Calcium gluconate injection)and containing both monovalent and bivalent ion electrolyte were investigated by the change of appearance to determine the pH value,insoluble particles and the size and distribution(polydispersity index,PDI)within 24 h. RESULTS:The pH of the nutrition with electrolyte was over 5 and also met the quality requirements;there were no precipitate,flocculation and discoloration in the appearance;the neonatal parenteral nutrition containing only monovalent ion electrolyte appeared a small amount of hanging wall phenomenon for 24 h,but did not appear demulsification phenomenon;the neonatal parenteral nutrition containing only bivalent ion electrolyte appeared a small amount of hanging wall phenomenon and demulsification phenomenon for 24 h;the neonatal parenteral nutrition containing both monovalent and bivalent ion electrolyte appeared a small amount of hanging wall phenomenon and demulsification phenomenon for 12 h and the hanging wall phenomenon was more obvious for 24 h. Meanwhile,a size bigger than 5μm microns and particle size bigger than 25 μm microns of insoluble particles appeared,and both the average particle size and PDI value were higher than those in the previous two situations(P〈0.05). CONCLUSIONS:As more and more monovalent and bivalent ion electrolyte being added into the neonatal parenteral nutrition,especially divalent ion electrolyte,the stability of the neonatal parenteral nutrition decreases,which behaves as a phenomenon that the size of grains and the number of insoluble particles increase.
出处 《中国药房》 CAS 北大核心 2015年第25期3493-3495,共3页 China Pharmacy
关键词 电解质 新生儿肠外营养液 稳定性 粒径 不溶性微粒数 Electrolyte Neonatal parenteral nutrition Stability Particle size Insoluble particles
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