摘要
抗癌治疗是当今世界性难题。分析癌细胞与正常细胞可以发现两者之间具有对立斗争、相互依存、消长平衡以及相互转化等矛盾双方的基本关系特征,因此矛盾原理可用于指导癌症的研究和治疗。根据矛盾原理,抗癌治疗不能局限于单纯杀伤和消灭癌细胞,诱导其休眠和逆转也是治疗的重要策略,同时正常细胞也应该是治疗的靶点,抗癌治疗对其影响应该得到重视,揭示两种细胞之间的调控机制,有助于发现新的癌症监测分子并开发新的分子生物学治疗策略。
Cancer treatment remains a serious problem worldwide. Analysis on the relationship between cancer cells and normal cells has revealed that this two kinds of cells share the characteristics of the two as- pects in a contradiction, thus could be analyzed by using contradictory principle. Under the guidance of con- tradictory principle, induction of a dormant state or reversal of cancer cells are important treatment strategies besides killing them. Normal cells also should be the targets and influences of treatment targeting cancer ceils on normal cells should be considered. Findings based on the pathway crosstalks between the two kinds of cells may offer opportunities for the development of new biomarkers and therapies.
出处
《生命的化学》
CAS
CSCD
2015年第4期543-548,共6页
Chemistry of Life
基金
国家自然科学基金项目(81402063)
陕西省优势学科建设经费(基础医学)
四川中医药高等专科学校课题(14ZRZD01)
陕西省2014年省级大学生创新创业训练计划项目(2014118401661)
关键词
矛盾原理
癌细胞
正常细胞
癌症治疗
contradictory principle
cancer cells
normal cells
cancer treatment
