摘要
目的:了解我院儿科病例中葡萄球菌属对红霉素及克林霉素的不同耐药表型的发生率,促进儿科抗菌药物的合理使用。方法:采用K-B纸片法检测葡萄球菌对红霉素和克林霉素的耐药性。按照NCCLS推荐的D-试验检测克林霉素诱导型耐药表型。结果:53株葡萄球菌属中,5株对红霉素和克林霉素均敏感,23株对红霉素和克林霉素均耐药,MRSA和MRCNS的发生率分别为61.1%(11/18)、60.0%(9/15);4株对红霉素耐药而对克林霉素中敏;21株对红霉素耐药而对克林霉素敏感,其中D-试验阳性14株,占红霉素耐药而克林霉素敏感总菌株的66.7%,占总菌株的26.4%。MSSA、MRSA、MSCNS、MRCNS中Er-R且Cl-S的发生率分别为66.7%(6/9)、27.8%(5/18)、54.5%(6/11)、26.7%(4/15),其中D-试验阳性发生率分别为60.0%、66.7%、50.0%和83.3%。结论:我院儿科患者感染中葡萄球菌克林霉素诱导型耐药率较高,细菌室应对儿科标本常规开展D-试验,避免克林霉素的无效治疗,为儿科医师合理选用抗菌药物提供及时、准确地参考依据。
Objective： To investigate the incidence of different resistance phenotypes of erythromycin induced clindamycin to Staphylococcus in pediatric hospital and promote the rational use of antimicrobial drugs pediatrics. Methods： K-B method was used to detect Staphylococcus to erythromycin and clindamycin resistance, according to NCCLS recommended D-test for detection of inducible clindamycin resistance phenotype. Results： We detected fifty three Staphylococcus, five pairs were sensitive to erythromycin and clindamycin. Twenty-three pairs were resistant to erythromycin and clindamycin, the incidence of MRSA and MRCNS were 61. 1% （ 11/18 ）, 60.0% （9/15）. Four strains were resistant to erythromycin and intermediary to clindamycin. Twenty-one pairs were resistant to erythromycin and sensitive to clindamycin, 14 pairs were D-test positive, accounting resistant to erythromycin and sensitive to clindamycin strains of 66.7% overall, 26.4% of the total strains. Incidence rates of MSSA, MRSA, MSCNS, MRCNS in Er-R and C1-S were 66.7% （6/9）, 27.8% （5/18）, 54.5% （6/11）, 26.7% （4/15）, D-test positive rates were 60.0% , 66.7%, 50.0% and 83.3%. Conclusion： Pediatric patiems in our hospital Staphylococcus inducible clindamycin resistance rate is higher, we can carry out routine D-tests in pediatric specimen to avoid elindamycin treatment failure, provide timely, accurate reference to pediatricians the rational use of antimicrobial agents.
出处
《儿科药学杂志》
CAS
2015年第9期33-35,共3页
Journal of Pediatric Pharmacy
基金
徐州市临床药学课题
项目编号XZZDY1309
