摘要
多囊卵巢综合征(Polycystic Ovary Syndrome,PCOS)是育龄期女性最常见的内分泌及代谢紊乱性疾病,约70%的患者存在脂代谢异常,增加了罹患心脑血管疾病的风险,严重威胁着PCOS患者的生命和健康。其发病机理可能与载脂蛋白A1[Apolipoprotein(a)-1,Apo A1]、脂代谢相关调控因子、脂联素、瘦素以及内脂素及其相关基因的异常表达有关。目前尚缺乏PCOS脂代谢异常的研究方法以及特异性的治疗药物和手段。中医药改善PCOS患者脂代谢紊乱疗效明确,具有多靶点、多环节、多途径效应,可以同时调节PCOS患者内分泌与代谢紊乱,且相对安全。应用代谢组学的方法开展中医药对PCOS脂代谢影响机制的研究具有重要意义,将为中医药防治PCOS脂代谢异常的推广应用提供科学依据。
Polycystic ovary syndrome （PCOS） is the most common endocrine and metabolic disorders in reproductive age women. About 70% of PCOS patients have abnormal lipid metabolisms, which increases the risk of suffering from cardiovascular diseases. This has pose a threat to their life and health. The possible pathogenesis may relate to the abnormal expression of ApoA1, the regu- lation factors of lipid metabolism, adiponectin, leptin, visfatin and corresponding genes. However, currently, there are in lack of drugs and instruments for the targeted treatment of PCOS with abnormal lipid metabolisms. Previous studies have confirmed that Traditional Chinese Medicine is effective to improve the conditions of abnormal lipid metabolisms in patients with PCOS, which has the effects of multi-target, multi-link, and multi-channel. Furthermore, it can also improve the endocrine and metabolic disorders in patients with PCOS with a relatively dale approach. It is significant to carry out the mechanism researches to observe the effects of Traditional Chinese Medicine on PCOS with abnormal lipid metabolism by the method of metabolomics, which will provide scien- tific basis for the popularization of Traditional Chinese Medicine for the treatment of PCOS with abnormal lipid metabolism.
出处
《世界中医药》
CAS
2015年第7期1112-1116,共5页
World Chinese Medicine
基金
广州医科大学2014年博士启动项目(编号:2014C29)
针刺对多囊卵巢综合征脂代谢影响的代谢组学研究--广州医科大学2014年博士启动项目(编号:2014C29)
关键词
多囊卵巢综合征
脂代谢异常
中医药
代谢组学
Polycystic ovary syndrome
Abnormal lipid metabolisms
Traditional Chinese Medicine
Metabolomics
