摘要
门静脉高压症是肝硬化重要的并发症,严重影响了患者的生存质量。开发治疗门静脉高压症的药物一直是该领域的研究热点。β-受体阻断剂及其他药物因为各种不良反应大大限制了其临床应用。随着中医对门静脉高压症病机认识的深入以及中药有效组分的研究进展,中药在治疗门静脉高压症方面取得了一些进展。治疗门静脉高压症的单味药物包括丹参、当归、泽泻、冬虫夏草等;复方包括扶正化瘀胶囊、复方861、抗纤软肝颗粒、复方鳖甲软肝片、强肝软坚汤、加味瓜蒌散、肝络通等。这些单味药以及复方在抗纤维化以及降低门静脉压力方面都显示出治疗作用。通过总结中药在治疗肝硬化门静脉高压症方面的研究进展,旨在为降低门静脉压力,从而降低曲张静脉破裂出血的风险提供更多选择。
Portal hypertension （PHT） is an important complication of liver cirrhosis and affects the quality of patients＇ life serious- ly. Since PHT was first proposed, finding a perfect medicine for PHT has been the foeus of this field. Because of their contraindi- cations or side effects, β-receptor blockers and other drugs can＇t be suitable for long-term administration. With the advances of tra- ditional Chinese medicine （TCM） in the pathogenesis of PHT, it has made some progress in the treatment of PHT. The single Chi- nese herbs include Salvia, angelica, Rhizoma alismatis and Cordyceps. The compounds include Fu zheng hua yu capsule, com- pound 861, Kang xian Ruan gan Granule, Bie jia ruan gan pian, Qiang gan Ruan jian decoction, jia wei gua lou san, Glytan etc. These single drug and compounds have shown therapeutic effect on liver fibrosis and PHT. The aim of this summary is to provide more choices to reduce portal pressure, thereby reduce the risk of bleeding from oesophageal variees.
出处
《世界中医药》
CAS
2015年第7期1120-1123,共4页
World Chinese Medicine
基金
北京市自然基金资助项目(编号:7144223)
关键词
门静脉高压症
中药
静脉曲张破裂出血
Portal hypertension
Traditional Chinese medicine
Varieeal bleeding
