期刊文献+

乳腺神经内分泌癌七例病理特征及预后分析 被引量:2

原文传递
导出
摘要 目的:分析乳腺神经内分泌癌的病理特征及预后情况。方法回顾性分析山西省肿瘤医院2008年1月至2013年7月收治的7例乳腺神经内分泌癌患者的病理特征、临床特点、治疗及预后。结果7例乳腺神经内分泌癌患者均为女性,年龄41~60岁,平均年龄52.3岁,均以无痛性乳腺肿物就诊。患者病理特征具有神经内分泌癌的形态学特点,免疫组织化学染色结果突触素阳性6例,抗神经特异性烯醇化酶阳性6例,嗜铬素A阳性5例,雌激素受体阳性6例,孕激素受体阳性6例,CerbB-2阳性1例,p53阳性1例。术后随访9~24个月(平均15.6个月),患者均无瘤生存,无复发及远处转移。结论该7例乳腺神经内分泌癌患者的发病年龄低于国外报道,该病预后与其他乳腺癌类型无明显差异,均与临床分期及病理分型有关。有关乳腺神经内分泌癌的治疗及预后仍需大样本及长时间的随访观察。
出处 《肿瘤研究与临床》 CAS 2015年第7期484-486,共3页 Cancer Research and Clinic
  • 相关文献

参考文献13

  • 1Tang F, Wei B, Tian Z, et al. Invasive mammary carcinoma with neuroendocrine differentiation:histological features and diagnostic challenges [ J ]. Histopathology, 2011,59 ( 1 ) : 106-115.
  • 2Righi L, Sapino A, Marchio C, et al. Neuroendoerine differentiation in breast cancer: estabilished facts and un resolved problems [ J ]. Semin Diagn Pathol, 2010, 27 ( 1 ) : 69-76.
  • 3Rovera F, Masciocchi P, Coglitore A, et al. Neuroendocrine carcinomas of the breast [ J ]. Int J Surg, 2008, 6 ( Suppl 1 ) : S113- Sl15.
  • 4程虹,戴林,郭双平.乳腺及女性生殖器官肿瘤病理学和遗传学[M].北京:人民卫生出版社,2006.1-124.
  • 5Ajisaka H, Maeda K, Miwa A, et al. Breast cancer with endocrine differentiation: report of two cases showing different histologic patterns [ J ]. Surg Today, 2003, 33 ( 12 ) : 909-912.
  • 6Cubilla AL, Woodruff JM. Primary carcinod tumor of the breast.A case report of eight patients [ J ]. Am J Surg Pathol, 1977, 1 ( 3 ) : 283-292.
  • 7Tavassoli F, Devile P. WHO classification of tumours : pathology and genetics of the breast and female genital organs [ M ]. Lyon :IARC Press, 2003: 32-34.
  • 8Sapion A, Righi L, Cassoni P, et al. Expression of the neuroendocrine phenotype in carcinomas of the breast [ J ]. Semin Diagn Pathol, 2000, ( 17 ) : 127-137.
  • 9Zekioglu O, Erhan Y, Ciris M, et al. Neuroendocrine differentiated carcinomas of the breast: a distinct entity [ J ]. Breast, 2003, 12 (4) : 251-257.
  • 10Baselga J, Carbonell X, Castaneda-Soto NJ, et al. Phase H study of efficacy, safety, and pharmacokinetics of trastuzumab monotherapy administered on a 3-Weekly Schedule [ J ]. J CIin Oncol, 2005, 23 ( 10 ) : 2162-2171.

共引文献35

同被引文献16

引证文献2

二级引证文献1

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部