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阿尔茨海默病与氧化应激 被引量：15

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摘要 关于阿尔兹海默病(AD)的病因和病理生理机制有多种假说,其中氧化应激假说认为AD的标志性病变β-淀粉样蛋白(Aβ)和磷酸化Tau等,能刺激活性氧簇(ROS)的生成,引起氧化应激,损伤神经元,引起认知功能障碍。氧化应激状态的持续激活进一步促进Aβ和磷酸化Tau的聚集和沉积、线粒体损伤,导致AD的发生并加速其病理进程。
作者 宋玉菲 付剑亮
机构地区 上海交通大学附属第六人民医院神经内科
出处 《国际神经病学神经外科学杂志》 北大核心 2015年第3期290-293,共4页 Journal of International Neurology and Neurosurgery
关键词 阿尔茨海默病 氧化应激 活性氧簇 Β-淀粉样蛋白
分类号 R749.16 [医药卫生—神经病学与精神病学]
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参考文献28

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二级参考文献52

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共引文献10

同被引文献144

引证文献15

二级引证文献84

国际神经病学神经外科学杂志
2015年 第3期

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