摘要
目的 分析良性前列腺增生（BPH）合并细菌性前列腺炎与人类乳头瘤病毒的关系以及应用不同治疗方案的临床疗效,总结最佳的临床治疗方案.方法 将120例BPH合并细菌性前列腺炎患者随机分为常规组及观察组两组,每组60例.常规组接受常规西医治疗,观察组在常规组治疗的同时给予前列舒乐颗粒口服治疗.再选用未婚无性经历男性患者39例作为对照组,对所有研究对象前列腺液取材后行HPV（人乳头瘤病毒总型）PCR检测,分别对比常规组与观察组治疗前后的国际前列腺症状（I-PSS）评分、慢性前列腺炎症状（NIH-CPSI）评分及前列腺体积改善情况.同时对比两组临床治疗总有效率及药物副作用发生率.结果 对照组研究对象HPV（总型）呈阴性,良性前列腺增生（BPH）合并细菌性前列腺炎患者阳性率为17.5％ （21/120）,两组患者存在差异（P＜0.05）,治疗前两组I-PSS评分、NIH-CPSI评分及前列腺体积比较均未见统计学差异（P＞0.05）,但治疗1个月后,观察组以上指标改善均明显优于常规组（P＜0.05）.同时观察组治疗总有效率明显优于常规组（P＜0.05）.结论 良性前列腺增生（BPH）合并细菌性前列腺炎与人乳头瘤病毒关系密切,并且在常规治疗的基础上应用前列舒乐颗粒治疗可有效的提高临床治疗效果.
Objective To analysis the relationship between Human papilloma virus and benign prostatic hyperplasia （BPH） with bacterial prostatitis and to investigate clinical efficiencies of different treatment methods,so as to provide a best therapeutic scheme to the doctor.Methods One hundred and twenty cases of BPH complicated with bacterial prostatitis were randomly divided into the routine group and the observation group,60 cases in each group.The routine group was received conventional western medicine treatment and the observation group was received Qianlieshule granule and western medicine treatment.Another thirtynine unmarried male patients with no sexual experience were selected as control group.HPV （human papilloma virus type） PCR detection was used to analyze prostate fluid samples of all subjects before and after treatment respectively.International Prostate Symptom Score （I-PSS）,chronic prostatitis symptom score （NIH-CPSI） and prostatic volume improvement were compared between the routine group and the observation group before and after treatment.The total efficiency and the side effects of drugs were compared between the two groups.Results There was no positive case of HPV in control groups.The positive rate of HPV in the routine group and the observation group was 17.5% （21/120）.The difference was statistically significant （P〈 0.05）.There was no significant difference of International Prostate Symptom Score （I-PSS）,chronic prostatitis symptom score （NIH-CPSI） between two groups before treatment （P 〉 0.05）.The difference was significant with one month treatment （P 〈 0.05）.The total efficiency of the observation group was higher than that of the routine group （P 〈 0.05）.Conclusions BPH complicated with bacterial prostatitis was closely related with human papilloma virus infection,and therapeutic scheme of Qianlieshule granule combined with conventional treatment can improve the effect of clinical treatment effectively.
出处
《国际病毒学杂志》
2015年第4期228-231,共4页
International Journal of Virology
关键词
良性前列腺增生
细菌性前列腺炎
人乳头瘤病毒
前列舒乐颗粒
治疗方案
Benign prostatic hyperplasia
Bacterial prostatitis
Human papilloma virus
Qianlieshule granule
Therapeutic scheme
