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Effect of Inonotus Obliquus Polysaccharides on physical fatigue in mice 被引量:4

Effect of Inonotus Obliquus Polysaccharides on physical fatigue in mice
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摘要 OBJECTIVE: To evaluate the potential beneficial effects of Inonotus obliquuspolysaccharides(IOP) on the alleviation of physical fatigue in mice.METHODS: Sixty-four male mice were randomly divided into four groups(n = 16 per group). Mice were orally administered IOP for a period of 14 days at 0,100,200 and 300 mg/kg/d,and were assigned to the control,IOP-100,IOP-200,and IOP-300 groups,respectively by the random number table method. Mice in the control group received an oral administration of sterile distilled water. A forced swimming test was performed for 8 mice per group at one hour after the last treatment. The other 8mice in each group swam for 30 min. Blood,liver and muscle samples were taken after resting for30 min. Levels of blood urea nitrogen and lactate,as well as glycogen contents of the liver and muscle were measured. Morphology of liver was observed by light microscopy.RESULTS: IOP extended the swimming time of mice,and increased the glycogen content of liver and muscle,but decreased blood lactic acid and serum urea nitrogen levels. IOP had no toxic effects on major organs such as the liver as assessed by histopathological examinations.CONCLUSION: IOP might be a potential anti-fatigue pharmacological agent. OBJECTIVE: To evaluate the potential beneficial effects of Inonotus obliquuspolysaccharides(IOP) on the alleviation of physical fatigue in mice.METHODS: Sixty-four male mice were randomly divided into four groups(n = 16 per group). Mice were orally administered IOP for a period of 14 days at 0,100,200 and 300 mg/kg/d,and were assigned to the control,IOP-100,IOP-200,and IOP-300 groups,respectively by the random number table method. Mice in the control group received an oral administration of sterile distilled water. A forced swimming test was performed for 8 mice per group at one hour after the last treatment. The other 8mice in each group swam for 30 min. Blood,liver and muscle samples were taken after resting for30 min. Levels of blood urea nitrogen and lactate,as well as glycogen contents of the liver and muscle were measured. Morphology of liver was observed by light microscopy.RESULTS: IOP extended the swimming time of mice,and increased the glycogen content of liver and muscle,but decreased blood lactic acid and serum urea nitrogen levels. IOP had no toxic effects on major organs such as the liver as assessed by histopathological examinations.CONCLUSION: IOP might be a potential anti-fatigue pharmacological agent.
出处 《Journal of Traditional Chinese Medicine》 SCIE CAS CSCD 2015年第4期468-472,共5页 中医杂志(英文版)
基金 Supported by Science and Technology Research program of Jilin Province,Education Department in the 12th Five Year Plan(China)(Research on Prevention of Inonotus Obliquus Polysaccharides for High Power Microwave Radiation Induced Injury in Rats,No.2012495)
关键词 Polysaccharides Fatigue Blood urea ni-trogen Lactic Acid Glycogen Anatomy and histolo-gy Pharmacological phenomena 雄性小鼠 身体疲劳 菌多糖 体力 口服给药 强迫游泳 组织病理学 肌糖原
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