摘要
目的：观察注射用头孢西丁钠在0．9％氯化钠注射液中与地塞米松磷酸钠的配伍稳定性。方法：25℃室温环境下将头孢西丁钠与地塞米松磷酸钠注射液在0．9％氯化钠注射液中配伍，采用高效液相色谱法测定0～6h内配伍药液中头孢西丁钠的含量变化，观察配伍药液的外观，并检测药液pH值变化。结果：测定结果显示，配伍液0～6h内头孢西丁钠的含量无明显变化，pH值基本不变，外观及性状无变化，不溶性微粒符合规定。结论：头孢西丁钠与地塞米松磷酸钠6h内在0．9％氯化钠注射液中可以配伍。
Objective： To observe the compatible stability of eefoxit[n sodium in O. 9% sodium chloride injection and dexamethasone sodium phosphate. Methods： The cefoxitin sodium was compatible with dexamethasone sodium phosphate in 0. 9% sodium chloride injection at 25%. HPLC was used to determine the change of cefoxitin sodium content in the compatible liquids within 0-6h. The appearance of pharmaceutical liquids was observed, and the change of pH value was detected. Results： No obvious change of cefoxitin sodium content in the compatible liquids within 0-6h, and no change of PH value, appearance, and characteristics were observed. The insoluble particles conformed to the specifications. Oonclusions： Cefoxitin sodium can be compatible with dexamethasone sodium phosphate in 0.9% sodium chloride injection within 6 h.
出处
《海南医学院学报》
CAS
2015年第10期1316-1317,1321,共3页
Journal of Hainan Medical University
基金
宣钢集团科技进步项目(2012066303)~~
