摘要
目的探讨CRP+1444C/T基因多态性与子宫内膜癌(EC)的相关性。方法选择203例EC患者(EC组)和同期健康体检者203名(对照组),采用聚合酶链反应-限制性片段长度多态性(PCR-RELP)方法检测CRP+1444C/T基因多态性,并结合血清超敏CRP(hs CRP)水平及其他临床资料进行分析。结果 EC组的血清hs CRP高于对照组(P<0.05),2组的CRP+1444C/T基因型和等位基因的分布相近,比较差异无统计学意义(P>0.05)。与子宫内膜癌BMI<25 kg/m2(正常)者相比,BMI≥25 kg/m2(超重)者CC基因型及C等位基因频率较高(P<0.05);且超重者CC基因型组的hs CRP水平高于CT+TT基因型组(P<0.05)。结论 CRP+1444C/T基因多态性可能和包括胰岛素抵抗以及炎症因子在内的某些机制共同作用,影响子宫内膜癌的发病风险。
Objective To investigate the potential association between C-reactive protein（ CRP）gene ＋ 1444 C / T polymorphism and endometrial cancer. Methods In this study,203 patients with endometrial cancer（ EC） and 203 healthy controls were enrolled into the EC and control groups. The CRP gene ＋ 1444 C / T polymorphism was determined by polymerase chain reaction-restriction fragment length polymorphism（ PCR-RFLP）. The serum hsCRP levels combined with alternative clinical data were determined for subsequent analysis. Results The serum hsCRP level in the EC group was significantly higher compared with that in the control group（ P〈0. 05）. No statistical significance was documented in the frequencies of CC,CT and TT genotypes between two groups（ P〉 0. 05）. Compared with EC patients with normal BMI（ 〈25 kg / m^2）,a significantly higher frequency of CC genotype and C allele type was found in those with BMI≥25 kg / m^2（ P〈0. 05）. In addition,women with CC genotype or C allele type had significantly higher serum hsCRP levels compared with those with CT and TT genotypes or T allele type（ both P〈0. 05）. Conclusion CRP gene ＋ 1444 C / T polymorphism,insulin resistance and inflammatory factors may collectively affect the risk of EC.
出处
《新医学》
2015年第8期515-519,共5页
Journal of New Medicine
基金
广东省医学科研基金(B2012105)
