摘要
冠心病发生率、致死率高,严重危害人类健康。心肌缺血再灌注损伤是加重心肌损伤的主要病理机制,干预再灌注损伤挽救激酶、单磷酸腺苷激酶、蛋白激酶C等信号传导通路保护心肌,成为减轻心肌损伤的重要途径之一。综述近3年国际期刊收录的中药有效成分、提取物及复方制剂调节相关信号传导通路,减轻心肌再灌注损伤的研究进展,以期为阐释中药的作用特点,有效防治心血管疾病提供参考。
With high incidence and mortality rate, coronary heart disease（CHD） poses great threat to human health. Myocardial ischemia/reperfusion injury is the major pathological mechanism that aggregates myocardial damage. Intervention in signaling pathways of reperfusion injury salvage kinase（RISK）, adenosine 5＇-monophosphate（AMP）-activated protein kinase and protein kinase C, etc plays an important role in attenuation of myocardial reperfusion injury. Many traditional Chinese medicines（TCMs） can protect against myocardial ischemia reperfusion（I/R） injury. The present review highlights the advance in researches（published in international journals in recent 3 years） on signaling transduction pathways regulated by TCM（including effective components, extracts and compound preparations） in the protection against myocardial I/R injury, so as to provide references for elucidation of acting mechanisms of TCM and effective prevention of cardiovascular diseases.
出处
《药学进展》
CAS
2015年第6期425-436,共12页
Progress in Pharmaceutical Sciences
基金
国家自然科学基金(No.81274004)
江苏省高校优势学科建设项目
关键词
心肌梗死
心肌缺血再灌注损伤
中药
心肌保护
信号传导通路
myocardial infarction
myocardial ischemia reperfusion injury
traditional Chinese medicine
cardioprotection
signal transduction pathway
