摘要
目的探讨唑来膦酸对合并骨关节炎的绝经后骨质疏松症(Postmenopuasal osteoporosis,PMOP)患者的影响。方法选取我院2010年2月至2014年5月收治的98例合并骨关节炎的绝经后骨质疏松症患者为研究对象,采用随机数字表法分为观察组和对照组各49例,对照组予以钙剂(碳酸钙D3片600 mg qd)、活性维生素D(阿法骨化醇软胶囊0.25 ug qd)基础补充治疗,同时予以玻璃酸钠25 mg qw关节腔内注射治疗;观察组在上述药物治疗基础上联合唑来膦酸5 mg一年一次静脉滴注治疗。研究比较两组治疗前后膝关节功能lysholm评分、疼痛VAS评分、生活质量评分(SF-36)以及腰椎及股骨的骨密度变化。结果 Lysholm与VAS评分:治疗6、12个月后,观察组膝关节功能lysholm评分显著高于对照组,VAS评分显著低于对照组(P<0.05);骨密度:治疗6、12个月后,观察组L1-L4、Ward’s三角、股骨颈、股骨Troch等部位骨密度显著高于对照组(P<0.05);生活质量:观察组PF、RP、BP、GH、VT、SF、RE、MH、Total评分均显著高于对照组(P<0.05)。结论唑来膦酸有助于缓解合并骨关节炎的绝经后骨质疏松症患者疼痛程度,增加骨密度,改善膝关节功能,提高生活质量。
Objective To study the effect of zoledronic acid on the treatment of postmenopausal osteoporosis（ PMOP） patients complicated with osteoarthritis. Methods Ninety-eight postmenopausal osteoporotic patients complicated with osteoarthritis in our hospital from February 2010 to May 2014 were selected. They were randomly divided into the observation group and the control group.There were 49 patients in each group. The patients in control group received oral calcium carbonate D3 600 mg and alfacalcidol soft capsules 0. 25 ug per day,and intra-articular injection of 25 mg sodium hyaluronate per week. In the treatment group,all the patients received intravenous injection of 5mg zoledronic acid once per year on the basis of the same treatment in the control group. The knee joint function（ Lysholm score）,pain（ VAS score）,life quality score（ SF-36）,and bone mineral density of the lumbar spine（ L1-L4）,femoral neck,Ward＇s triangle,and the Troch region were examined and compared between the two groups. Results Lysholm score was significantly higher in the observation group than in control group,but VAS score was significantly lower than in control group after 6- and 12-month treatment（ P〈0. 05）. Bone mineral density of the L1-L4,Ward＇s triangle,femoral neck,and Troch in the observation group was significantly higher than that in the control group（ P〈0. 05）. The life quality evaluation showed that PF,RP,BP,GH,VT,SF,RE,MH,and total scores in the treatment group were significantly higher than those in the control group（ P〈0. 05）. Conclusion Zoledronic acid is beneficial in releasing the pain in PMOP patients complicated with osteoarthritis. It can also increase bone mineral density,improve knee joint function,and improve the life quality.
出处
《中国骨质疏松杂志》
CAS
CSCD
北大核心
2015年第8期986-989,共4页
Chinese Journal of Osteoporosis
关键词
绝经后骨质疏松症
骨关节炎
唑来膦酸
骨密度
生活质量
Postmenopausal osteoporosis
Osteoarthritis
Zoledronic acid
Bone mineral density
Quality of life
