摘要
目的探讨急性冠状动脉综合征患者TIMI危险评分与血浆N末端前脑利钠肽(NTpro-BNP)水平及血清肌钙蛋白Ⅰ(TNⅠ)的相关性。方法收集2013年5月至2014年9月在该院接受治疗的98例急性冠状动脉综合征患者,按照患者的临床指标对患者进行TIMI危险评分,根据评分将患者分为低危组(n=23)、中危组(n=34)、高危组(n=41),采用AQT快速免疫分析法检测患者血浆NTpro-BNP及TNⅠ水平,研究TIMI危险评分、NTpro-BNP及TNⅠ的相关性。结果 TIMI评分在单支、双支、三支病变间差异有统计学意义(P<0.01)。临床上对于不同分型疾病的判断具有一致性,差异有统计学意义(P<0.01)。TIMI危险评分能够有效预测患者的心血管不良事件发生情况,其中3组患者治疗后6个月均较3个月和治疗期的不良事件发生率高,高危组各个时期的不良事件发生率较低危和中危组高,差异有统计学意义(P<0.01)。低危、中危、高危组患者随着TIMI危险评分的升高,NTpro-BNP和BNP水平均升高,NTpro-BNP升高更加显著(P<0.01)。Spearman等级相关分析可知,NTproBNP与TIMI呈正相关(P<0.01),与TNⅠ呈正相关(P<0.05);TIMI与TNⅠ相关性差异无统计学意义(P>0.01)。结论急性冠脉综合征患者TIMI危险评分与NTpro-BNP相关性良好,而且与TNⅠ无相关性。
Objective To discuss the correlation TIMI risk score to plasma N terminal pro brain natriuretic peptide（NTpro- BNP）level and serum troponin I （TN I ） in patients with acute coronary syndrome. Methods Totally 98 cases of acute coronary artery from May,2013 to September,2014 treated in our hospital with syndrome TIMI risk score were observed,According to the score, the patients were divided into low risk group（n=23）, middle risk group（n=34） and high risk group（n=41）, and NTpro- BNP and TN I levels were detected by AQT rapid immunoassay. The correlation of TtMI and NTpro-BNP and TN I were studied.. Results TIMI scores in single,double,triple disease have statistically significant differences（P〈0.01）. The adverse event incidence of the high risk group was higher than the middle risk group and the low risk group（P〈0.01）. TIMI risk score was effective in predicting adverse cardiovascular events, patients in the 3 groups after 6 months of treatment all had higher incidence of adverse events than that of the 3 month and the treatment period,the incidence of adverse events in high risk group was significantly higher than that in low risk group and middle risk group（P〈0.01）. Low risk group, the middle group, the high risk group of patients with the increase of TIMI risk score, NTpro-BNP and BNP levels were elevated, NTpro-BNP increases more significantly,can be used to identify high risk patients, （P〈0.01）. Spearman rank correlation analysis shows that NTpro-BNP was relation to TIMI （P〈0.01）, and NTpro-BNP had positive correlation with TN I （P〈0.05） ;TIMI no statistically significant correlation with TN I （P〉0.01）. Conclusion TIMI risk score in patients with acute coronary syndromes has significant correlation with NTpro-BNP, but has no correlation with TN I .
出处
《重庆医学》
CAS
北大核心
2015年第25期3547-3549,共3页
Chongqing medicine
