摘要
【目的】采用3.0T磁敏感加权成像(SWI)分析"燕尾征"在非帕金森病者黑质中存在的普遍性,探讨其缺失对帕金森病(PD)的影像诊断价值。【方法】对60例临床确诊的PD患者(PD组)及非PD志愿者(N-PD组)行3.0 TMR磁敏感加权成像,在幅度图上对N-PD组志愿者黑质内"燕尾征"的形态及数量进行分析,并与PD组患者相应区域影像表现进行对照。【结果】排除脑干病变及运动伪影较大的15例患者后,N-PD组49例(96.08%)均在双侧或单侧黑质致密部后外侧见典型"燕尾征";PD组所有54例(100%)"水滴"后方椭圆形高信号均表现缺失,两组差异有统计学意义(P<0.05)。【结论】在3.0T SWI幅度图上非PD者黑质内普遍存在"燕尾征"表现;该征象的缺失对PD的诊断具有极高的灵敏度及特异性。
【Objective】 To analyze the universality of the ＂swallow tail＂ appearance in the healthy nigra at 3.0T SWI, and to explore the diagnostic value of its loss in Parkinson＇s disease. 【Methods】 A total of 60 patients diagnosed with Parkinson＇s disease（PD group）, and 60 non-Parkinson＇s disease volunteers（N-PD group） were scanned with 3.0T SWI. To analyze the shape, number of＂swallow tail＂ appearances within the N-PD group of volunteers in the magnitude imaging, and compared with the corresponding region in patients of PD group. 【Results】 15 cases with brainstem lesions or heavier motion artifacts were excluded. N-PD group,＂swallow tail＂ appearances were displayed in 49 cases（96.08%） in bilateral or unilateral of the SN; PD group, all 54 cases（100%）of the ＂swallow tail＂ appearances completely disappeared. The difference was statistically significant（P 0.05） 【Conclusions】Typical＂swallow tail＂ appearances are prevalent in the substantia nigra of non-Parkinson＇s disease people in the magnitude imaging at 3.0T MR SWI; the sensitivity of its loss for the diagnosis of Parkinson＇s disease up to 100% and the specificity of it about 96.08%.
出处
《中山大学学报（医学科学版）》
CAS
CSCD
北大核心
2015年第4期635-640,共6页
Journal of Sun Yat-Sen University:Medical Sciences
基金
襄阳市科技计划研究与并发项目(襄科业201411)
关键词
帕金森病
磁敏感加权成像
黑质
Parkinson＇s disease
susceptibility weighted imaging
substantia nigra
