摘要
目的观察四逆汤加减治疗阳虚型高血压病的临床疗效。方法 121例阳虚型高血压病患者随机分为对照组61例、治疗组60例,对照组给予钙离子拮抗剂(每粒5 mg)、β-受体阻滞剂(每粒5 mg)和血管紧张素转化酶抑制剂(每粒4 mg)或血管紧张素Ⅱ受体拮抗剂(每粒100 mg),每日1次,每次1粒。治疗组在对照组治疗基础上加四逆汤加减治疗,每日1剂,两组均连续治疗8周。观察治疗前后两组患者诊室血压、24 h动态血压(24 h平均血压、24 h血压标准差)变化,治疗后评价临床疗效。结果治疗组中医证候疗效总有效率为86.67%,对照组为59.02%,治疗组明显优于对照组(P<0.05)。两组治疗后诊室及24小时平均收缩压均明显降低(P<0.01)。对照组治疗后24 h收缩压标准差、24小时夜间收缩压标准差与治疗前比较均明显降低(P<0.05或P<0.01);治疗组治疗后24小时白天收缩压标准差、24小时夜间收缩压标准差与治疗前比较均明显降低(P<0.01);治疗组治疗后24 h收缩压标准差、24 h夜间收缩压标准差水平明显低于对照组(P<0.05)。结论四逆汤加减治疗阳虚型高血压病疗效显著,可有效改善血压变异性。
Objective To observe clinical efficacy of modified Sini Tang treating hypertension of Yang deficiency type. Methods Totally 121 patients with hypertension belong to Yang deficiency type were randomly divided into control group of 61 cases and treatment group of 60 cases. The control group was given calcium antagonist（ 5 mg per tablet）,β-receptor blocker（ 5 mg per tablet） and angiotensin converting enzyme inhibitors（ 4 mg per tablet） or angiotensin Ⅱreceptor antagonist（ 100 mg per capsule）,once a day for 1 capsule. In the treatment group,based on the medication of the control group,added modified Sini Tang,1 dose per day,and both groups are continuously treated for 8 weeks. The authors observed the change of blood pressure in consulting room and 24 h ambulatory blood pressure（ 24 h average blood pressure,24 h blood pressure standard deviation） in the two groups before and after treatment and evaluated clinical efficacy. Results The TCM syndrome total effective rate was 86. 67% in the treatment group,and 59. 02% in the control group. The treatment group was superior to the control group（ P〈0. 05）.After treatment,both blood pressure in consulting room and 24 h average systolic of two groups significantly decreased（ P〈0. 01）. In the control group,24 h and nocturnal systolic pressure standard deviation significantly decreased after treatment（ P〈0. 05 or P〈0. 01）. In the treatment group,24 h diurnal and 24 h nocturnal systolic pressure standard deviation significantly decreased after treatment（ P〈0. 01）. The level of 24 h and 24 h nocturnal systolic pressure standard deviation in the treatment group after treatment was much lower than those in the control group（ P〈0. 05）.Conclusion Modified Sini Tang has obvious curative effect to treat hypertension belong to Yang deficiency type and can effectively improve blood pressure variability.
出处
《中医杂志》
CSCD
北大核心
2015年第17期1483-1486,共4页
Journal of Traditional Chinese Medicine
基金
上海市科学技术委员会科研计划项目(14DZ2273200)
关键词
四逆汤
高血压病
血压变异性
Sini Tang（四逆汤）
hypertension
blood pressure variability
