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孕晚期妇女产道定植性B群链球菌的耐药性及耐药机制研究 被引量：9

Epidemiology and Resistance Mechanisms of Group B Streptococci in Late-pregnant Maternal Birth Canal
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摘要 目的了解孕晚期妇女产道内B群链球菌(group Bstreptococci,GBS)的耐药现状和相关耐药机制,为国内孕妇产道GBS预防治疗及抗生素的合理应用提供理论及数据支持。方法纳入31例产道有GBS定植的孕晚期妇女,对分离出的GBS菌株进行药物敏感实验,对红霉素和克林霉素耐药的菌株进行耐药表型分析和耐药基因检测。结果 21株(67.7%)对红霉素耐药,12株(38.7%)对克林霉素耐药,其中有12株为固有型耐药表型(cMLS型),9株为主动外排型耐药表型(MS型)。在红霉素耐药菌株中有11株检测到mef(A)基因,12株检测到erm(B)基因,其中有3株同时检测到erm(C)基因。结论孕晚期妇女产道内分离出的GBS菌株对大环内酯类抗生素耐药率较高,对红霉素耐药的GBS菌株的耐药机制以erm(B)基因介导的核糖体靶位改变和mef(A)基因介导的特异大环内酯类外排机制增强为主。 Objective To study the antibiotic-resistant rate of group B streptococci （GBS） in obstetric canal of late-pregnant women, evaluate the antibiotic-resistant status and finally to support the GBS prevention and curing by proper antibiotics. Methods 31 pregnant women between 35 to 37 gestational weeks were included, for whom the antibiotic sensitivity as well as the drug （erythromycin and clindamycin） resistance genes of GBS in obstetric canal was analyzed. Results 12 （38. 7%） strains of GBS were resistant to clindamycin, while 21 （67. 7%） to erythromycin, within which 12 strains were intrinsic phenotype cMLS type-clindamycin resistance, other 9 were active efflux phenotype MS type-clindamyein sensitive and all of which were confirmed by Double disk diffusion method. Eleven strains were rnef （A） positive, and 12 strains were erm （B） positive, in which 3 with erm （C）. Conclusions In our research the GBS strains show a high erythromycin and clindamycin resistance rate. The resistance of our GBS strains are mainly caused by the ribosomal target changes induced by errn （B） and the increased efflux of elindamycin induced by reef （A）.
作者 旷凌寒 母丽媛 苏敏 周伟 江咏梅
机构地区 四川大学华西第二医院临床检验科
出处 《四川大学学报（医学版）》 CAS CSCD 北大核心 2015年第5期692-696,共5页 Journal of Sichuan University(Medical Sciences)
关键词 无乳链球菌 孕妇 定植 耐药 耐药机制 Streptococcus agalactiae Pregnant woman Colonization Resistance Resistance mechanism
分类号 R714.25 [医药卫生—妇产科学] R446.5 [医药卫生—诊断学]
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参考文献22

  • 1Schrag S. Gorwitz R. Fultz-Butts K. et al. Prevention of perinatal group B streptococcal disease. Revised guidelines from CDC. MMWR Recomm Rep.2010;5ICRR-11): 1-22.
  • 2Castor ML, Whitney CG. Corno-Sabetti K. et al . Antibiotic resistance patterns in invasive group B streptococcal isolates. Infect Dis Obstet Gynecol.2008;2008:727505. doi , 10.1155/ 2008/727505.
  • 3Valkenburg-van den Berg AW. Houtman-Roelofsen RI. Oostvogel PM. et al . Timing of group B streptococcus screening in pregnancy: a systematic review. Gynecol Obstet Invest. 2010; 69( 3) : 174-183.
  • 4Phares CR. Lynfield R. Farley MM. et al . Epidemiology of invasive group B streptococcal disease in the United States. 1999-2005. J AMA. 2008; 299 (17) : 2056-2065.
  • 5RANZCOG. Maternal Group B Streptococcus in Pregnancy: screening and management. RANZCOG statement C-Obs 19. Melbourne: Royal Australian and New Zealand College of Obstetricians and Gynaecologists. 2012: 1-19.
  • 6Leclercq R. Mechanisms of resistance to macrolides and lincosarnides , nature of the resistance elements and their clinical implications. Clin Infect Dis. 2002; 34( 4) : 482-492.
  • 7Suzanne MG. Erin Cv Lisa M.etal. Antimicrobial resistance in group B streptococcus: the Australian experience. J Med Microbiol.2011;60(Pt 2) :230-235.
  • 8申阿东,张桂荣,王咏红,杨永弘.B组链球菌的耐药性及红霉素耐药基因检测研究[J].中华儿科杂志,2005,43(9):661-664. 被引量：15
  • 9Perez-Trallero E. Montes M. Orden B. et al . Phenotypic and genotypic characterization of Streptococcu spyogenes isolates displaying the MLSB phenotype of macrolide resistance in Spain. 1999 to 2005 . Antimicrob Agents Cherncther , 2007; 51 (4) :1228-1233.
  • 10周义正,李高莲,邱晓燕,王昌富.B群链球菌耐药性及红霉素耐药机制的研究[J].中国微生态学杂志,2011,23(1):66-68. 被引量：7

二级参考文献19

  • 1申阿东,张桂荣,王咏红,杨永弘.B组链球菌的耐药性及红霉素耐药基因检测研究[J].中华儿科杂志,2005,43(9):661-664. 被引量：15
  • 2EMILIO P T, MONTES M, ORDEN B, et al. Phenotypic and genotypic characterization of Streptococcus pyogenes isolates displaying the MLSB phenotype of maerolide resistance in Spain, 1999 to 2005[ J]. Antimicrob Agents Chemother,2007,51 (4) : 1228 -1233.
  • 3FRANKLIN R, COCKERILL M A W, KAREN, et al. Performance standards for antimicrobial susceptibility testing; twentieth informational supplement M100-S20 [ S ]. Clinical and Laboratory Standards Institute, 2010.
  • 4DERMER P, LEE C,EGGERT J,et al. A history of neonatal group B streptococcus with its related morbidity and mortality rates in the United States [ J ]. J Pediatr Nurs ,2004 ,19 (5) : 357-363.
  • 5GRANIZO .I J,AGUILAR L,CASAL J,et al. Streptococcus pyogenes resistance to erythromycin in relation to macrolide consumption in Spain ( 1986-1997 ) [ J ]. J Antimicrob Chemother,2000,46 (6) :959 -964.
  • 6HEELAN J S, HASENBEIN M E, MeADAM A J. Resistance of group B streptococcus to selected antibiotics, including erythromycin and clindamycin[ J]. l Clin Microbiol,2004,42 (3) : 1263-1264.
  • 7ALOS J I,ARACIL B,OTEO Let al. High prevalence of erythromycin-resistant, clindamycin/miocamycin-ausceptible (M phenotype) Streptucoccus pyogenes: rosults of a Spanish multicentre study in 1998. Spanish Group for the Study of Infection in the Primary Health Care Setting[ J]. J Antimicrob Chemother,2000,45 ( 5 ) :605-609.
  • 8American College of Obstetricians and Gynecologists. Prevention of early-onset group B streptococcal disease in newborns. Int J Gynaecol Obstet,2003,81:115-122.
  • 9Prevention of perinatal group B streptococcal disease: a public health perspective. Centers for Disease Control and Prevention. MMWR Recomm Rep,1996,45(RR-7):1-24.
  • 10Andrews JI, Diekema DJ, Hunter SK, et al. Group B streptococci causing neonatal bloodstream infection: antimicrobial susceptibility and serotyping results from SENTRY centers in the Western Hemisphere. Am J Obstet Gynecol,2000,183:859-862.

共引文献19

同被引文献107

  • 1黄素静,徐秋霞,韦秋圆,许琳,关红琼.高龄产妇产褥期感染影响因素及血清IL-6和PCT与TNF-α水平[J].中华医院感染学杂志,2021,31(24):3803-3806. 被引量：5
  • 2申阿东,张桂荣,王咏红,杨永弘.B组链球菌的耐药性及红霉素耐药基因检测研究[J].中华儿科杂志,2005,43(9):661-664. 被引量：15
  • 3韩旭,辛德莉,李靖,陈晓庚,马少杰.氯霉素、利福平对肺炎支原体的抗菌活性分析[J].实用儿科临床杂志,2007,22(22):1739-1741. 被引量：12
  • 4Dhanoa A, Karunakaran R, Puthucheary S. Serotype distribu-tion and antibiotic susceptibility of group B streptococci in pregnant women[ J]. Epidemiol Infect, 2010, 138 (7) :979 - 981. DOI: 10. 1017/S0950 268809991105.
  • 5Chattopadhyay D, Carey A J, Caliot E, et al. Phylogenetic lineage and pi- lus protein Spbl/SAN1518 affect opsonin-independent phagocytosis and intracellular survival of Group B Streptococcus [ J 1. Microbes Infect, 2011,13 (4) :369 - 382. DOI : 10. 1016/j. micinf. 2010.12. 009.
  • 6Yu HW, Lin HC, Yang PH, et al. Group B streptococcal infection in Tai- wan:maternal colonization and neonatal infection [ J ]. Pediatr Neonatol, 2011,52 (4) : 190 - 195. DOI : 10. 1016/j. pedneo. 2011.05. 008.
  • 7Verani JR, McGee L, Schrag SJ, et al. Prevention of perinatal group B streptococcal disease--revised guidelines from CDC, 2010 [ J]. MMWR Recomm Rep ,2010 ,59 ( RR - 10 ) : 1 - 36.
  • 8Centers for Disease Control and Prevention ( CDC ). Decreasing inci- dence of perinatal group B streptococcal disease--United States, 1993 - 1995 [J]. MMWR Morb Mortal Wkly Rep,1997, 46(21 ) :473 -477.
  • 9Savoia D, Gottimer C, Crocilla' C, et al. Streptococcus agalactiae in preg- nant women : pbenotypie and genotypic characters [ J ]. J Infect,2008,56 (2) : 120 - 125. DOI : 10. 1016/j. jinf. 2007.11. 007.
  • 10Sadowy E, Matynia B, Hryniewicz W. Population structure, virulence fac- tors and resistance determinants of invasive, non-invasive and colonizing Streptococcus agalaetiae in PolandE J]. J Antimicrob Chemother,2010, 65 (9) : 1907 - 1914. DOI : 10. 1093/jac/dkq230.

引证文献9

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四川大学学报（医学版）
2015年 第5期

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