摘要
目的:探讨鼻炎康片治疗常年性变应性鼻炎的疗效及对患者血清白介素4(IL-4)、白介素8(IL-8)及免疫球蛋白lg E水平的影响。方法:选取2013年1月—2014年12月常年性变应性鼻炎患者96例为研究对象,随机分为观察组和对照组,各48例。对照组:给予丙酸氟替卡松鼻喷雾剂治疗。观察组:给予丙酸氟替卡松鼻喷雾剂联合鼻炎康片治疗。观察并比较两组患者的疗效及血清IL-4、IL-8及免疫球蛋白lg E的水平。结果:观察组总有效率89.58%高于对照组总有效率77.08%,差异具有统计学意义(P<0.05)。治疗后,观察组患者EOS含量(24±7)×103cell/m L低于对照组患者EOS含量(28±9)×103cell/m L,差异具有统计学意义(P<0.01)。治疗后,观察组血清IL-4(48.53±13.27)pg/m L、IL-8(162.79±55.64)pg/m L、Ig E(1 252.75±161.78)IU/m L都低于对照组血清IL-4(57.32±19.71)pg/m L、IL-8(193.29±62.05)pg/m L、Ig E(1 325.86±170.24)IU/m L,差异均有统计学意义(P<0.05)。结论:丙酸氟替卡松鼻喷雾剂联合鼻炎康片治疗常年性变应性鼻炎疗效显著,可以改善患者血清IL-4、IL-8及Ig E水平。
Objective： To investigate the effect of Biyankang tablets in treatment of perennial allergic rhinitis and its intervention on the serum levels of Interleukin 4（IL-4）,interleukin 8（IL-8） and immunoglobulin lg E. Method： A total of 96 patients with perennial allergic rhinitis from January 2013 to December 2014 in our hospital as the research object,were randomly divided into observation group and control group,48 cases in each. Control group： Fluticasone Propionate Nasal Spray treatment. The observation group： Fluticasone Propionate Nasal tablets Spray combined with Biyankang treatment. We observed and compared the efficacy and serum IL-4,IL-8 and immunoglobulin lg E in patients of two groups. Results： Total effective rate of observation group was 89. 58%,higher than that of the control group＇s total effective rate 77. 08% and the difference was statistically significant（P〈0. 05）. After treatment,the content of EOS（24 ± 7） × 103 cell/m L in the observation group was lower than the control group＇s（28 ± 9） × 103 cell/m L and the difference was statistically significant（P 0. 01）. After treatment,the serum levels of IL-4（48. 53 ± 13. 27） pg/m L,IL-8（162. 79 ± 55. 64） pg/m L,Ig E（1 252. 75± 161. 78） IU/m L in the observation group were lower than the control group＇s serum levels of IL-4（57. 32 ± 19. 71） pg/m L,IL-8（193. 29 ± 62. 05） pg/m L,Ig E（1 325. 86 ± 170. 24） IU/m L and the difference was the statistically significant（P〈0. 05）. Conclusion： Fluticasone Propionate Nasal Spray combined with Biyankang tablets in treatment of perennial allergic rhinitis has good curative effect and can improve the serum IL-4,IL-8 and Ig E levels in patients.
出处
《中华中医药学刊》
CAS
北大核心
2015年第9期2213-2215,共3页
Chinese Archives of Traditional Chinese Medicine
基金
浙江省医药卫生一般研究计划项目(2012KYA174)
关键词
常年性变应性鼻炎
鼻炎康片
丙酸氟替卡松鼻喷雾剂
炎症因子
perennial allergic rhinitis
Biyankang tablets
Fluticasone Propionate Nasal Spray
inflammatory factor
