摘要
目的：探讨尿微量蛋白肌酐比值（UACR）评估急性冠脉综合征（ACS）患者冠脉病变程度的临床价值。方法选取江苏省徐州市中心医院2011年9月-2014年9月收治的649例ACS患者,纳入患者组,并按照其UACR水平分为微量白蛋白尿（MA）阴性组与阳性组,同时选取300名健康体检者,纳入正常组。比较各组受试者血糖、血脂、C反应蛋白（CRP）、UACR等指标差异,分析UACR与患者冠脉病变严重程度Gensini积分的相关性。结果 MA阳性组空腹血糖（FBS）、低密度脂蛋白胆固醇（LDL-C）、CRP、UACR显著高于MA阴性组及正常组（P〈0.05）,其三酰甘油（TG）显著高于正常组（P〈0.05）,但与MA阴性组比较,差异无统计学意义（P〉0.05）。 MA阳性组冠脉多支病变百分比及严重冠脉病变百分比分别为87.1%、72.5%,均显著高于MA阴性组的47.1%、21.4%（P〈0.05）。UACR与冠脉病变支数、Gensini积分均呈正相关（P〈0.05）。Logistic回归分析可见,UACR、LDL-C对患者冠脉病变程度有较高的预测价值（P〈0.05）。结论 UACR能够明确ACS患者冠脉病变程度,是一种快速、简单、无损伤性检测方法,在早期病情判断及干预方案的制订中有重要指导价值。
Objective To investigate the clinical value of urinary albumin-to-creatinine ratio （UACR） on the evaluation of coronary artery disease extension of patients with acute coronary syndrome （ACS）. Methods 649 cases of patients with ACS were selected into the patients group, who had treated in Xuzhou Central Hospital of Jiangsu Province from September 2011 to September 2014. All the patients were divided into MA positive group and MA negative group ac-cording to the level of UACR. 300 cases of healthy people were selected into the control group. The differences in blood glucose, blood lipid, C reaction protein （CRP）, UACR and other indicators were compared between groups, and the correlation between UACR and the lesion extent of coronary Gensini score was analyzed. Results The FBS, LDL-C, CRP, UACR of MA positive group were significantly higher than the MA negative group and normal group （P 0.05）. The percentages of coronary artery multi-vessel lesions and severe le-sions of MA positive group （87.1%, 72.5%） were higher than MA negative group （47.1%, 21.4%） （P〈0.05）. There were positively correlation between UACR and the Gensini score, number of coronary artery lesions （P〈0.05）. The results of Logistic regression showed UACR, LDL-C had highly values for the evaluation of ACS （P〈 0.05）. Conclusion UACR can clear the extent of coronary lesions of ACS. It is a rapid, simple, non-invasive detection method, which has an im-portant guidance for the early evaluation and intervention for ACS.
出处
《中国医药导报》
CAS
2015年第26期61-64,共4页
China Medical Herald
关键词
尿微量蛋白肌酐比值
急性冠脉综合征
冠脉病变程度
评估
临床价值
Urinary albumin-to-creatinine ratio
Acute coronary syndrome
Degree of coronary artery lesions
Evalu-ation
Clinical value
