摘要
目的制备甘草酸脂质体,评价其在小鼠肝脏中的靶向性。方法以薄膜分散-超声法制备甘草酸脂质体,于小鼠尾静脉给药,RP-HPLC法测定肝脏和血液中不同时间的药物浓度。以甘草酸注射剂为对照,通过相对摄取率(re)、靶向效率(te)和峰浓度比(Ce)3个参数来评价脂质体的肝靶向效率。结果甘草酸脂质体肝脏相对摄取率re=1.4;甘草酸脂质体肝靶向效率te=0.092;甘草酸注射液te=0.059,肝脏中Ce=1.59,血液中Ce=0.99。结论与甘草酸注射剂相比,甘草酸脂质体有明显的肝靶向性。
Objective To prepare liposomes of glycyrrhizic acid,and evaluate its liver targeting property in mice.Methods The liposomes were prepared with conventional rotary-evaporated film-ultrasonication method. The liposomes were injected into the mouse tail vein,and the concentration of glycyrrhizic acid was detected by RP-HPLC. The glycyrrhizic acid injection was taken as control. The targeted indicators,including the relative tissue exposure（ re）,targeting efficiency（ te）,and index of peak concentration ratio（ Ce）,were used to evaluate the liver targeting property. Results The rewas 1. 4,Teof the liposomes was 0. 092,and teof the injection was 0. 059. The Ceof the liver was 1. 59,and the Ceof the blood was 0. 99. Conclusion Compared with glycyrrhizic acid injection,the glycyrrhizic acid liposomes show good liver-targeting property.
出处
《中国实验动物学报》
CAS
CSCD
北大核心
2015年第4期401-405,共5页
Acta Laboratorium Animalis Scientia Sinica
基金
陕西省教育厅科学研究计划项目(编号:2013JK0775)
关键词
甘草酸
脂质体
肝靶向
Glycyrrhizic acid
Liposome
Liver targeting property
Mice
