摘要
目的 研究手术治疗结直肠癌同时肝转移患者的生存状况,探讨影响患者生存率和生存时间的因素.方法 选取2010年5月～2014年5月接受同期结直肠癌和肝转移瘤切除手术治疗的结直肠癌同时肝转移的患者100例,统计患者的生存率和生存时间,应用log-rank检验及Cox模型分析影响患者生存状况的因素.结果 患者术后生存期7～110个月,半数生存期为37个月,3年生存率为56.68％,5年生存率为35.43％.应用log-rank筛选出影响结直肠癌同时肝转移患者术后生存状况的相关因素：原发瘤的T分期、分化程度、术前CEA水平、肝转移灶大小、数量与患者预后相关.多因素分析显示,术前CEA水平、肝转移瘤的大小及肝转移灶数量是影响结直肠癌同时肝转移患者术后预后的重要因素.结论 结直肠癌同时肝转移患者肝转移瘤的数量、大小与术前CEA水平是影响患者术后生存状况的重要因素,患者应积极进行手术治疗,同期切除病变组织,以提高生存率.
Objective To study the living conditions of patients with colorectal cancer with synchronous liver metastasis with operation, and explore the factors influencing patients survival rate and survival time. Methods 100 colorectal cancer patients with synchronous liver metastases were selected from May 2010 to May 2014 in our hospital underwent resection of colorectal cancer and liver metastases from surgical treatment. The survival rate and survival time of patients were counted, log - rank test and Cox model to analyze factors of influencing the survival state were applied. Resuits Postoperative survival time of patients was 7-110 months. The median survival time was 37 months. Three year survival rate was 56.68~, and five year survival rate was 35.43%. The T stage, primary tumor differentiation degree, preoperative CEA levels, the prognosis of patients with liver metastases size, quantity were the related factors. Multifactor analysis showed that the preoperative level of CEA, liver metastases and the number of liver metastases is liver metastasis in patients with coloreetal cancer and an important factor of postoperative outcomes. Conclusion The size and the number of liver metastases of patients with eolorectal cancer liver metastases and preoperative CEA level are the main factors that influence the survival conditions of patients. Patients should be actively treated, diseased tissue at the same time, in order to improve the survival rate.
出处
《西部医学》
2015年第9期1303-1305,共3页
Medical Journal of West China
基金
国家自然科学基金(30901720)
关键词
结直肠癌
肝转移
生存状况
Colorectal cancer
Spread to the liver
Living conditions
