摘要
三阴乳腺癌(triple negative breast cancer,TNBC)是一种特殊的乳腺癌亚型,侵袭性强、预后差,近年来受到广泛关注。本文综述了TNBC的临床病理学、分子生物学特征及治疗进展。临床病理学包括流行病学、临床特点及病理生物学特征。分子生物学特征包括TNBC与Basal-like乳腺癌、乳腺癌1号基因(breast cancer 1,BRCA1)、p53等基因间的关系。治疗包括手术治疗、新辅助化学治疗、高剂量化学治疗及靶向治疗。深入研究TNBC的特征可为其治疗提供更多新思路。
Triple negative breast cancer（TNBC ） is defined as one of the subtypes of breast cancer, which has been attracted much attention in recent years because of the aggressive behavior and inferior prognosis. This review summarizes clinical pathologic features, molecular biologic features and treatments of TNBC. Clinical pathologic features include epidemiologic, clinical and pathobiologic features. Molecular biologic features demonstrate the relationship between TNBC and basal-like breast cancer, breast cancer 1 （ BRCA1 ） and p53 gene. Treatments include surgery, neoadjuvant chemotherapy, high dose chemotherapy and targeted therapy. Further research in TNBC may provide more effective therapies.
出处
《首都医科大学学报》
CAS
北大核心
2015年第4期578-582,共5页
Journal of Capital Medical University
基金
国家自然科学基金(81172518)
北京市科技新星交叉合作项目(Z14111000180000)
北京市卫生系统高层次卫生技术人才培养计划项目(2014-2-016)
首都医科大学附属北京妇产医院学科带头人项目(2013-1)~~
关键词
三阴乳腺癌
特征
治疗
进展
triple negative breast cancer
feature
treatment
progression
