期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

粘着斑激酶和血管内皮生长因子在唾液腺腺样囊性癌中的表达及意义 被引量：6

Expression of focal adhesion kinase and vascular endothelial growth factor in salivary adenoid cystic carcinoma and their significances
原文传递
导出
摘要 目的探讨粘着斑激酶(FAK)和血管内皮生长因子(VEGF)在唾液腺腺样囊性癌(SACC)中的表达及意义。方法采用SP免疫组织化学方法检测40例SACC、15例正常唾液腺组织中FAK、VEGF、CD34的表达情况。实验数据采用SPSS 19.0统计软件进行Mann-Whitney U检验、方差分析和Fisher′s精确经验,FAK和VEGF表达进行相关分析。结果 40例SACC组织中FAK阳性表达率为87.5%(35/40),对照组为33.33%(5/15),Z=-4.44,P=0.001;VEGF阳性表达率为90%(36/40),对照组为26.67%(4/15),Z=-4.84,P=0.001;CD34阳性表达率为85%(34/40),对照组为40%(6/15),Z=-4.18,P=0.002,差异均有统计学意义;FAK和VEGF在SACC中的表达与肿瘤血管生成之间具有关联(FFAK=8.86、PFAK=0.01;FVEGF=8.18、PVEGF=0.01);FAK和VEGF在SACC中的表达与肿瘤的临床分期以及远处转移有关联(P<0.05),与患者的性别、年龄、肿瘤发生部位和大小、神经侵犯、病理分级、复发情况和淋巴结转移差异无统计学意义(P>0.05);FAK和VEGF在SACC中的表达存在正相关性(r=0.479,P=0.002)。结论 FAK和VEGF与SACC的发展及侵袭、转移有关联。 Objective To investigate the expression of focal adhesion kinase （FAK） and vascular endothelial growth factor （VEGF） in salivary adenoid cystic carcinoma （SACC） and their significances. Methods The expressions of FAK, VEGF and CD34 in 40 cases of SACC and 15 cases of normal salivary gland tissue were detected with immunohistochemical method. SPSS 19.0 software was used for Mann-Whitney U, Chi-square test, Fisher＇s exact test and correlation analysis. Results The expression of FAK was seen in 87.5% of SACC and 33.33% in the control group, Z=-4.44, P =0.001; The expression of VEGF was 90% and 26.67% respectively, Z=-4.84, P=0.001; The expression of CD34 was 85% and 40% respectively, Z=-4.18, P=0.002. The differences were significant （P﹤0.05）. The expression of FAK and VEGF in SACC was associated with tumor angiogenesis（FFAK=8.86、PFAK=0.01;FVEGF=8.18、PVEGF=0.01）. The expression of FAK and VEGF was significantly associated with clinical stage and metastasis in the samples （P﹤0.05）, but did not correlate with sex, age, tumor diameter and pathological grade （P 〉 0.05）. The expression of FAK was positively correlated with the expression of VEGF. The coefficient of correlation was 0.479, P=0.002. Conclusion The expression of FAK and VEGF is significantly associated with tumor clinical stage clinical stage and metastasis.
作者 龚攀 欧阳可雄 陈凯 邝燕好 李劲松
机构地区 广州医科大学附属肿瘤医院口腔科 广州医科大学附属口腔医院口腔颌面外科 广东药学院附属第一医院口腔科 中山大学孙逸仙纪念医院口腔颌面外科
出处 《中华口腔医学研究杂志（电子版）》 CAS 2015年第4期9-12,共4页 Chinese Journal of Stomatological Research(Electronic Edition)
基金 国家自然科学基金(81272951 81472521) 广州医科大学青年科研项目(2014A37)
关键词 唾液腺腺样囊性癌 转移 粘着斑激酶 血管内皮生长因子 微血管密度 Salivary adenoid cystic carcinoma Metastasis Focal adhesion kinase Vascular endothelial growth factor Microvessel density
分类号 R739.8 [医药卫生—肿瘤]
  • 相关文献

参考文献13

  • 1Agulnik M, Cohen EW, Cohen RB, et al. Phase II study of lapatinib in recurrent or metastatic epidermal growth factor receptor and/or erbB2 expressing adenoid cystic carcinoma and non adenoid cystic carcinoma malignant tumors of the salivary glands [J]. J Clin Oncol, 2007,25(25):3978-3984.
  • 2Chen AM, Bucci MK, Weinberg V, et al. Intraoperative radiation therapy for recurrent head-and-neck cancer: the UCSF experience J]. Int J Radiat Oncol Biol Phys, 2007,67 (1): 122-129.
  • 3Triantafillidon K, Dimitrakopoilos J, Iordanidis F, et al. Management of adenoid cystic carcinoma of minor salivary glands[J]. J Oral Maxillofac Snrg, 2006,64(7):1114-1120.
  • 4张柯晴,吕坤聚,朱君祥.FAK、NF-κB及VEGF在非小细胞肺癌中的表达及临床意义[J].中国组织化学与细胞化学杂志,2014,23(6):529-533. 被引量：3
  • 5Barnes L, Eveson JW, Reichart P, et al. World Health Organization Classification of Tumours. Pathology and Genetics of Head and Neck Tumours[M]. Lyon: IARC Press, 2005:209-274.
  • 6Pan J, Tang T, Xu L, et al. Prognostic significance of expression of cyclooxygenase-2, vascular endothelial growth factor, and epidermal growth factor receptor in nasopharyngeal carcinoma [J]. Head Neck, 2013,35(9) : 1238-1247.
  • 7Weidner N, Semple JP, Welch WR, et al. Tumor angiogenesis and metastasis-correlation in invasive breast carcinoma [J]. N Engl J Med, 1991,324( 1 ) : 1-8.
  • 8McLean GW, Carragher NO, Avizienyte E, et al. The role of focal adhesion kinase in cancer - a new therapeutic opportunity [J]. Nat Rev Cancer, 2005,5(7) :505-515.
  • 9张斌,孙长伏.唾液腺腺样囊性癌FAK和PTEN蛋白的表达及意义[J].上海口腔医学,2005,14(6):578-581. 被引量：2
  • 10张斌,孙长伏,李岩峰,于涛,黄汉.阻断FAK表达对涎腺腺样囊性癌细胞SACC-LM的侵袭行为的影响[J].中华老年口腔医学杂志,2009,7(2):68-70. 被引量：4

二级参考文献38

共引文献11

同被引文献50

  • 1张斌,孙长伏.唾液腺腺样囊性癌FAK和PTEN蛋白的表达及意义[J].上海口腔医学,2005,14(6):578-581. 被引量：2
  • 2Agulnik M, Cohen EW, Cohen RB, et al. Phase II study of lapatinib in recurrent or metastatic epidermal growth factor receptor and/or erbB2 expressing adenoid cystic carcinoma and non adenoid cystic carcinoma malignant tumors of the salivary glands [J]. J Clin Oncol, 2007,25(25):3978-3984.
  • 3Chen AM, Bucci MK, Weinberg V, et al. Intraoperative radiation therapy for recurrent head-and-neck cancer: the UCSF experience J]. Int J Radiat Oncol Biol Phys, 2007,67 (1): 122-129.
  • 4Triantafillidon K, Dimitrakopoilos J, Iordanidis F, et al. Management of adenoid cystic carcinoma of minor salivary glands[J]. J Oral Maxillofac Snrg, 2006,64(7):1114-1120.
  • 5Barnes L, Eveson JW, Reichart P, et al. World Health Organization Classification of Tumours. Pathology and Genetics of Head and Neck Tumours[M]. Lyon: IARC Press, 2005:209-274.
  • 6Pan J, Tang T, Xu L, et al. Prognostic significance of expression of cyclooxygenase-2, vascular endothelial growth factor, and epidermal growth factor receptor in nasopharyngeal carcinoma [J]. Head Neck, 2013,35(9) : 1238-1247.
  • 7Weidner N, Semple JP, Welch WR, et al. Tumor angiogenesis and metastasis-correlation in invasive breast carcinoma [J]. N Engl J Med, 1991,324( 1 ) : 1-8.
  • 8McLean GW, Carragher NO, Avizienyte E, et al. The role of focal adhesion kinase in cancer - a new therapeutic opportunity [J]. Nat Rev Cancer, 2005,5(7) :505-515.
  • 9Carron CP, Meyer DM, Pegg JA, et al. A Peptidomimetic Antagonist of the intergrin alpha (v)beta3 inhibitis Leydig cell tumor growth and development of hypercalcemia of malignancy [J]. Cancer Res, 1998,58(9) : 1930-1935.
  • 10Avraham HK, Lee TH, Koh Y, et al. Vascular endothelial growth factor regulates focal adhesion assembly in human brain microvascular endothelial cells through activaction of the focal adhesion kinase and related adhesion focal tyrosine kinase[J]. J Bio Chem, 2003,278(38) :36661-36668.

引证文献6

二级引证文献18

中华口腔医学研究杂志（电子版）
2015年 第4期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部