摘要
[目的]探讨延边地区朝鲜族和汉族小学生肥胖和胰岛素抵抗（IR）与不同脂肪细胞因子的相关性.[方法]选择延边地区8~12岁朝鲜族和汉族小学生3 879例作为研究对象,测定肥胖指标和空腹血糖（FBG）、胰岛素、脂联素、瘦素及肿瘤坏死因子-α（TNF-α）水平.采用稳态模式评估法（HOMA）评估人体IR（HOMA-IR）.[结果]朝鲜族小学生体质量指数（BMI）、腰围（WC）、HOMA-IR、脂联素和瘦素水平分别为18.2±3.4,62.4±8.7,13.1（9.9~16.9）,3.3（2.1~4.3）和1.4（1.1~1.9）,汉族小学生分别为17.1±3.1,61.3±7.4,12.0（8.2~16.5）,4.1（2.7~5.6）和1.3（1.0~1.6）.BMI,WC及HOMA-IR与脂联素呈负相关关系,与瘦素及TNF-α呈正相关关系（P〈0.01）;朝鲜族和汉族小学生BMI,WC及HOMA-IR与不同脂肪细胞因子的相关性程度有所不同.[结论]延边地区小学生肥胖指标、HOMA-IR和脂肪细胞因子的分布特征存在明显的民族差异;BMI,WC及HOMA-IR与不同脂肪细胞因子的相关性程度有所不同,亦存在民族差异.
OBJECTIVE To analyze the effects of obesity and insulin resistance（IR）for different adipocytokines in Korean-Chinese and Han nationality pupils of Yanbian area.METHODSA total of 3 879 elementary school students aged 8-12 years old were selected.The index of obesity and fasting blood glucose（FBG）,insulin,adiponectin,leptin and tumor necrosis factor-alpha（TNF-α）levels were measured.The homeostasis model assessment（HOMA）method was used to estimate the human IR（HOMA-IR）.RESULTS The mean levels of BMI,WC,HOMA-IR,adiponectin and leptin were 18.2±3.4,62.4±8.7,13.1（9.9-16.9）,3.3（2.1-4.3）and 1.4（1.1-1.9）in Korean-Chinese pupils and were 17.1±3.1,61.3±7.4,12.0（8.2-16.5）,4.1（2.7-5.6）and 1.3（1.0-1.6）in Han nationality pupils,respectively. BMI, WC and HOMA-IR had negative correlation with adiponectin and positive correlation with leptin and TNF-α,and there were different correlations among BMI,WC,HOMA-IR and different adipocytokines in Korean-Chinese and Han nationality pupils.CONCLUSION There are ethnic differences in the distribution of BMI,WC,HOMA-IR and adipocytokines,and BMI,WC and HOMA-IR have different correlation with different adipocytokines also with ethnic differences in pupils of Yanbian area.
出处
《延边大学医学学报》
CAS
2015年第1期22-24,共3页
Journal of Medical Science Yanbian University
基金
国家自然科学基金项目(81160349
81260138)
吉林省教育厅基金项目(2012-4
2013-25)
