摘要
目的观察扶正抑瘤汤对结直肠癌化疗后患者机体免疫功能的影响。方法将76例结直肠癌化疗后患者按照随机数字表法分为对照组和观察组,每组38例。对照组给予金复康口服液口服,观察组给予扶正抑瘤汤剂口服,2组均连续治疗4周。评估2组治疗前后乏力、纳差、胃脘痞闷、口干、便干积分,检测治疗前后肿瘤坏死因子-α(TNF-α)、白细胞介素-1β(IL-1β)、IL-6及T淋巴细胞亚群水平。结果 2组治疗后乏力、纳差、胃脘痞闷、口干、便干积分均较治疗前明显升高(P均<0.05),且观察组升高程度较对照组更显著(P均<0.05)。2组治疗后TNF-α及CD3+、CD4+、CD8+、CD4+/CD8+水平均较治疗前明显升高(P均<0.05),IL-1β、IL-6水平均较治疗前明显降低(P均<0.05),且观察组升高或降低程度均明显优于对照组(P均<0.05)。结论扶正抑瘤汤能明显缓解结直肠癌化疗后患者的不适症状,增强患者机体免疫功能,值得临床深入研究运用。
Objective It is to observe the influence of Fuzheng Yiliu decoction （FZYLD） on the immunity of patients with colorectal cancer after chemotherapy. Methods 76 patients with eolorectal cancer after chemotherapy were randomly divided into control group and observation group with 38 cases in each group. The patients were treated with Jinfukang oral solution in the control group and with FZYLD in the observation group, 4 weeks for treatment in both groups. Before and after treatment, the clinical symptoms score were assessed, and the levels of TNF - α, IL - 1 β, IL - 6 and T lymphocyte subsets were detec- ted. Results After treatment, the symptoms score such as fatigue, anorexia, abdominal distension, dry mouth and constipation in both groups were markedly higher than before treatment （ all P 〈 0.05 ）, and the observation group was more pronounced than the control group （ all P 〈 0.05） ; the levels of TNF - α, CD3 ＋ , CD4＋, CD8＋ and the value of CD4 ＋/CD8 ＋ in both groups were markedly higher than before treatment（ all P 〈 0.05 ） , and the levels of IL - 1 β and IL - 6 was markedly lower than before treatment （ all P 〈 0. 05 ）, and the observation group was more pronounced than the control group （ all P 〈0. 05 ）. Conclusion FZYLD can effectively alleviate the uncomfortable symptom of patients with colorectal cancer after chemotherapy, strengthen the immunity of patients, it is worthy of further research and development.
出处
《现代中西医结合杂志》
CAS
2015年第27期2980-2982,共3页
Modern Journal of Integrated Traditional Chinese and Western Medicine
关键词
扶正抑瘤汤剂
结直肠癌
化疗
免疫功能
Fuzheng Yiliu decoction
colorectal cancer
chemotherapy
immunity
