摘要
目的探讨抗甲状腺药物致粒细胞缺乏患者发生医院感染的病原菌分布及其耐药性,为临床选择敏感抗菌药物提供参考。方法选取2010年5月-2013年5月34例甲状腺药物致粒细胞缺乏发生医院感染患者为研究对象,分析感染病原菌的分布和对抗菌药物的耐药性,所有数据采用SPSS16.0软件进行统计分析。结果粒细胞缺乏症患者医院感染部位以呼吸道感染为主占41.18%,其次为泌尿系和皮肤软组织,分别占26.47%和11.76%;共分离病原菌42株,其中革兰阴性菌19株占45.24%、革兰阳性菌20株占47.62%、真菌3株占7.14%;革兰阳性菌中金黄色葡萄球菌对万古霉素和美罗培南耐药率最低,均为0;主要革兰阴性菌则对美罗培南、亚胺培南耐药率最低,均为0;对其他抗菌药物的耐药率均>20.00%。结论甲状腺药物致粒细胞缺乏合并医院感染以呼吸道常见,加强细菌培养、药敏试验,早期应用敏感抗菌药物至关重要。
OBJECTIVE To explore the distribution and drug resistance of pathogens causing nosocomial infections in patients with agranulocytosis induced by anti-thyroid drugs so as to provide guidance for use of sensitive antibiotics.METHODS From May 2010 to May 2013,a total of 34 patients with anti-thyroid drugs-induced agranulocytosis complicated with nosocomial infections were recruited as the study objects,then the distribution and drug resistance of the pathogens causing infections were analyzed,and all the data were statistically analyzed with the use of SPSS16.0software.RESULTS Among the agranulocytosis patients complicated with nosocomial infections,the patients with respiratory tract infections（41.18%）were dominant,followed by the patients with urinary tract infections（26.47%）and the patients with skin and soft tissue infections（11.76%）.Totally 42 strains of pathogens have been isolated,including 19（45.24%）strains of gram-negative bacteria,20（47.62%）strains of gram-positive bacteria,and 3（7.14%）strains of fungi.Among the gram-positive bacteria,the drug resistance rates of the Staphylococcus aureus to vancomycin and meropenem were lowest（0）;the drug resistance rates of the main gramnegative bacteria to meropenem and imipenem were lowest（0）,and the drug resistance rates to other antibiotics were more than 20.00%.CONCLUSION The respiratory tract is the most common infection site of the patients with anti-thyroid drugs-induced agranulocytosis complicated with nosocomial infections.It is crucial to strengthen the bacterial culture,perform the drug susceptibility testing,and use sensitive antibiotics in early stage.
出处
《中华医院感染学杂志》
CAS
CSCD
北大核心
2015年第17期3976-3978,共3页
Chinese Journal of Nosocomiology
基金
河南省卫生厅基金资助项目(HW-2009B027)
关键词
甲状腺药物
粒细胞缺乏
医院感染
Anti-thyroid drug
Agranulocytosis
Nosocomial infection
