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孟鲁司特对不同分型慢性阻塞性肺病患者气道限闭的影响 被引量:2

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摘要 目的探讨孟鲁司特对不同分型的稳定期慢性阻塞性肺病(COPD)患者气道限闭的影响。方法选择2012年1月至2014年2月济南市第五人民医院收治的稳定期COPD患者87例,其中男53例,女34例,按痰嗜酸细胞计数将患者分为A组40例(嗜酸粒细胞〉3%)和B组47例(嗜酸粒细胞〈3%)。两组均给予孟鲁司特10mg,次,1次,d,连用8周。治疗前后记录FEV1、FVC、AFVC及AFEV1,计算AFVC/△FEV1(代表气道限闭改善程度)。结果治疗后两组FEV1、FVC、AFVC、△FEV1、AFVC/AFEV1有不同程度的改善。A组△FVC、AFEV1、AFVC/AFEV1分别为(210.5±72.3)ml、(61.5±27.3)ml、(3.55±1.15),B组分别为(132.5±69.6)ml、(58.5±24.3)ml、(2.38±1.04),两组间△FVC及△FVC/△FEV1差异有统计学意义(P〈0.05)。结论对气道有嗜酸粒细胞浸润的COPD患者,孟鲁司特可明显改善其肺功能及气道限闭状态,改善程度优于中性粒细胞浸润为主的COPD患者。
出处 《中国临床实用医学》 2015年第4期52-53,共2页 China Clinical Practical Medicine
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参考文献9

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