摘要
乳腺属于外分泌腺的一种,在雌性动物生殖周期中呈动态性变化。乳腺的发育可根据动物性别发育和繁殖时期的不同分为胚胎期、青春期前期、青春期、妊娠期、泌乳期和退化期。作者总结了上皮-基质(间质)之间相互作用对胚胎时期及出生后动物个体乳腺发育的影响,详细阐述了乳腺不同发育阶段不同种类激素所发挥的调控作用,并针对小鼠、人乳腺干细胞的发现及标记物进行简要描述。本综述旨在清晰、深入地揭示乳腺发育的基本过程及潜在的调控机理,为进一步了解乳腺相关方面的研究工作提供参考资料。
Mammary gland is a kind of exocrine glands and a dynamic organ.Structure of mammary gland changes throughout the female reproductive cycles.Development of mammary gland occurs in the defined stages that are closely linted to sexual development and reproduction,namely embryonic,prepubertal and pubertal stages,pregnancy,lactation and involution.In this review,the roles of epithelial-stromal（mesenchymal）interactions in embryonic and postnatal mammary development were summarized,elaborated the regulations of different kinds of hormones on the mammary development after pubertal stage,and described the discovery of mammary stem cell populations（MaSC）and selection markers of mice and human.The objective of this work was to learn the basic processes and potential regulation mechanisms of the mammary development to provide some help for the researchers in the field of mammary gland.
出处
《中国畜牧兽医》
CAS
北大核心
2015年第9期2411-2417,共7页
China Animal Husbandry & Veterinary Medicine
基金
国家自然科学基金(31170950)
吉林省自然科学基金(20140101139JC)
关键词
乳腺
上皮-基质(间质)
乳腺干细胞
mammary glands epithelial-stromal（mesenchymal） mammary stem cell
