摘要
目的:观察口腔扁平苔藓(OLP)患者口腔黏膜超微结构的特征以及病损区细胞凋亡的变化,探讨OLP的发病机制。方法:应用透射电镜技术观察OLP患者和正常对照口腔黏膜超微结构,应用流式细胞术检测上皮细胞的凋亡。结果:透射电镜下可见OLP患者口腔黏膜凋亡细胞增多,染色质边聚,并见凋亡小体。OLP患者病变组织上皮细胞的凋亡细胞百分率为(30.06±4.56)%,高于正常对照[(7.70±0.69)%](t=15.392,P<0.001)。结论:细胞凋亡异常在OLP的发生过程中有重要作用。
Aim： To evaluate the features of ultra microstructure and cell apoptosis in the oral membrane from patients with oral lichen planus （ OLP）, and investigate the pathogenesis of OLP. Methods： Transmission electron microscope （TEM） was used to observe the change of ultra microstructure of oral membrane from patients with OLP. Flow cytometry was used to study the apoptosis of the epithelial cells. Results： TEM showed that there were increased apoptosis cells and chromatin margination in oral membrane from patients with OLP, and apoptotic bodies came into being. The apoptosis per-centage was （30. 06 ± 4. 56）% in OLP group,higher than that [（7. 70 ± 0. 69）% ] in control group（t = 15. 392,P 〈0. 001）. Conclusion： The abnormal apoptosis may play an important role in the pathogenesis of OLP.
出处
《郑州大学学报（医学版）》
CAS
北大核心
2015年第4期485-487,共3页
Journal of Zhengzhou University(Medical Sciences)
基金
河南省科技厅基础与前沿技术研究计划项目142300410341
关键词
口腔扁平苔藓
超微结构
细胞凋亡
oral lichen planus
ultra microstructure
cell apoptosis
