摘要
目的建立本实验室检测舟山海岛妇女妊娠期特异的甲状腺激素的参考区间,并分析其在妊娠早期、中期、晚期的变化趋势。方法选择健康妊娠妇女300例,分别在妊娠早期（1周～12周）、妊娠中期（13周～27周）、妊娠晚期（28周～40周）进行甲状腺激素检测。经统计分析得到各组甲状腺激素的参考区间,并分析其不同时期的变化趋势。结果妊娠早期、中期、晚期TT3、TT4、FT4均显著高于未妊娠组,差异有统计学意义（P〈0.01）;FT3在妊娠早期最高,高于未妊娠组,差异有统计学意义（P〈0.01）;TT3、TT4、FT3、FT4在妊娠期随孕周逐渐下降。TSH在妊娠早期最低,并随孕周增加而逐渐升高,在妊娠晚期接近未妊娠组水平。结论了解妊娠期甲状腺激素变化规律,建立本地区妊娠期特异的甲状腺激素参考区间有助于临床诊断、治疗与测监妊娠期甲状腺疾病,降低不良妊娠结局的发生。
Objective To build the reference interval of specific thyroid hormones during pregnancy,and analyze the variation trends during the first trimester,the second trimester and the third trimester of pregnancy in Zhoushan island area. Methods Serum thyroid hormones levels were measured during the first trimester（ 1 w- 12 w）,the second trimester（ 13 w- 27 w） and the third trimester（ 28 w- 40 w） of 300 pregnant women. To obtain the reference interval of thyroid hormones and analyze the variation trends in different times according to statistic analysis. Results TT3,TT4,FT4 levels during gestation period were higher than that of the non- pregnancy group,and the difference had statistical significance（ P〈0. 01）. The highest level of FT3 was in the first trimester,and higher than that of the non- pregnancy group,and the difference had statistical significance（ P〈0. 01）.With the increase of the gestational weeks,the TT3,TT4,FT3,FT4 levels decreased during gestation period. TSH level was of the lowest in the first trimester,and increased with the increase of the gestational weeks. The TSH level neared that of the non-pregnancy group during the third trimester. Conclusion Understanding the change rules of thyroid hormones during the pregnancy,building the special reference interval of the region would be necessary for clinical diagnosis,treatment and monitoring thyroid disease during pregnancy,so as to reduce the percent of occurrence of adverse pregnancy.
出处
《中国卫生检验杂志》
CAS
2015年第17期2924-2927,共4页
Chinese Journal of Health Laboratory Technology
关键词
妊娠
甲状腺激素
参考区间
变化分析
Pregnancy
Thyroid hormones
Reference interval
Variation trend
