摘要
目的 探讨口服营养补充对维持性血液透析蛋白质能量消耗（PEW）患者的营养状况影响.方法 采取7分主观整体评估（SGA）方法对2013年1月～2014年12月在广州市红十字会医院血液净化中心进行维持性血液透析的患者192人进行PEW患病率调查,并对符合纳入标准的PEW患者62人随机分为对照组和口服营养补充组（ONS）,每组各31人,观察其干预前后SGA评分及营养状况指标的变化. 结果 本中心维持性血液透析患者PEW的患病率为39.1％（75/192）.与对照组比较,ONS干预后可明显改善血清白蛋白（37.19±1.54比35.18±5.11）g/L、前白蛋白（305.74±43.20比275.68±65.23） mg/L、转铁蛋白（1.43±0.25比1.28±0.25）g/L水平,差异有统计学意义（P＜0.05）;ONS可增加SGA评分、体质量、体质量指数、上臂围、上臂肌围,并降低血清C反应蛋白水平,但差异无统计学意义（P＞0.05）.两组间肱三头肌皮褶厚度、血清总三酰甘油、总胆固醇水平无明显差异（P＞0.05）.结论 维持性血液透析患者患者蛋白质能量消耗患病率高,口服营养补充可改善血液透析PEW患者的营养状况指标,有可能可改善血液透析患者的PEW状况.
Objective To study the effect of oral nutrition supplement on nutritional status in mainte- nance hemodialysis （MHD） patients with protein-energy wasting （PEW）. Method We investigated the prev- alence of PEW by the 7-point subjective global assessment （SGA） in 192 MHD patients treated in the Blood Purification Center of Guangzhou Red Cross Hospital in the duration from Jan. 2013 to Dec. 2014. Sixty-two MHD patients with PEW were randomly divided into control group （n=31） or oral nutrition supplement group （ONS, re=31）. Changes of SGA score and nutritional status markers after intervention were compared between the two groups. Result The prevalence of PEW was 39.1% （75/192） in our center. After intervention in ONS group, serum albumin （37.19±1.54 vs. 35.18±5.11 g/L）, prealbumin （305.74±43.20 vs. 275.68±65.23 mg/ L）, and transferrin （1.43±0.25 vs. 1.28±0.25 g/L） increased significantly （P〈0.05） as compared with those in control group. SGA score, body weight, body mass index, upper arm circumference, and arm muscle circum- ference increased and C reactive protein level decreased in ONS group but without statistical significance （P〉 0.05）. Triceps skinfold thickness, total serum triglyceride and cholesterol levels were indifferent between the two groups （P〉0.05）. Conclusion The prevalence of PEW was higher in MHD patients. Oral nutrition sup- plement can improve the nutritional status in MHD patients with PEW.
出处
《中国血液净化》
2015年第9期550-553,共4页
Chinese Journal of Blood Purification
基金
广东省科技计划项目基金(2013B021800071)
广东省医学科研基金项目(A2014556)
广州市医药卫生科技项目基金(20141A011024)
关键词
蛋白质能量消耗
血液透析
主观整体评估
营养状况
口服营养补充
Protein-energy wasting
Hemodialysis
Subjective global assessment
Nutritional status
Oral nutrition supplement
