摘要
目的研究一清胶囊抗甲型H1N1流感病毒作用。方法采用小鼠气管内注入甲型流感病毒鼠肺适应株A/PR/8/34（H1N1）病毒液建立病毒感染小鼠模型,以肺指数、肺指数抑制率、小鼠累积死亡率为指标,评价一清胶囊体内抗甲型H1N1流感病毒作用。结果 7.3 g·kg^-1一清胶囊（原生药）可降低病毒感染小鼠的肺脏指数（P〈0.05）和小鼠感染病毒后7~9 d内的死亡率（P〈0.01）。结论一清胶囊具有明显的抗甲型H1N1流感病毒作用。
OBJECTIVE To evaluate the antivirus effect of Yiqing capsule. METHODS Antivirus test in vivo of Yiqing capsule was carried out by intratracheal injection of influenza A strains A/PR/8/34（H1N1） strain in mice. The lung index, inhibition rate of lung index and death rate of mice were measured to observe the effect of anti-influenza A virus subtype H1N1 in vivo. RESULTS The 7.3 g·kg^-1 Yiqing capsule（crude） could significantly decrease the lung index of viral infected mice（P〈0.05） and the mortality of 7？9 d in viral infected mice（P〈0.01）. CONCLUSION Yiqing capsule has good effect of anti-influenza A virus subtype H1N1 in vivo.
出处
《中国现代应用药学》
CAS
CSCD
2015年第9期1056-1058,共3页
Chinese Journal of Modern Applied Pharmacy
