摘要
目的探讨夜间服用长效钙拮抗剂联合抗焦虑治疗对非杓型高血压合并焦虑症患者的降压效果。方法选取2011年6月—2014年6月在汕头市中心医院就诊的非杓型高血压合并焦虑症患者156例。采用随机数字表法,将156例患者分为A、B、C 3组,每组52例。A组同时口服氨氯地平和黛力新;B组仅口服氨氯地平;C组仅口服黛力新。服药4周后行动态血压监测,评价患者血压及其形态变化。结果 (1)治疗前,3组24 h平均收缩压(24 h SBP)、白天平均收缩压(d SBP)、夜间平均收缩压(n SBP)、24 h平均舒张压(24 h DBP)、白天平均舒张压(d DBP)、夜间平均舒张压(n DBP)比较,差异均无统计学意义(P>0.05)。治疗后,3组24 h SBP、d SBP、n SBP、24 h DBP、d DBP、n DBP比较,差异有统计学意义(P<0.05);且B、C组与A组比较,差异有统计学意义(P<0.05)。治疗后,A、B组24 h SBP、d SBP、n SBP、24 h DBP、d DBP、n DBP与治疗前比较,差异有统计学意义(P<0.05)。(2)治疗后,A、B、C组患者恢复杓型高血压的比例分别为76.9%(40/52)、40.4%(21/52)、5.8%(3/52),3组恢复杓型高血压比例比较,差异有统计学意义(χ2=24.60,P<0.05);且A组与B组(χ2=14.31,P<0.05)、A组与C组(χ2=54.28,P<0.05)、B组与C组(χ2=17.40,P<0.05)比较,差异均有统计学意义。(3)3组疗效比较,差异有统计学意义(H=41.58,P<0.05);且A组与B组(H=7.88,P<0.05)、A组与C组(H=16.34,P<0.05)、B组与C组(H=10.72,P<0.05)比较,差异均有统计学意义。结论与夜间单独服用长效钙拮抗剂治疗和单独抗焦虑治疗相比,联合治疗对非杓型高血压合并焦虑症患者的降压效果更好。
Objective To explore the antihypertensive efficacy of nighttime administration of long - term calcium antagonist combined with anti - anxiety therapy on patients with non - dipper type hypertension and anxiety disorder. Methods We enrolled 156 patients with non - dipper type hypertension and anxiety disorder who received treatment from June 2011 to June 2014. Using random number table,we divided 156 patients into A,B and C group,with each group 52 subjects. Group A was administrated orally with amlodipine and deanxit,group B was administrated orally only with amlodipine,and group C was administrated orally only with deanxit. Four weeks after administration began,ambulatory blood pressure was monitored,and blood pressure and morphologic changes were evaluated. Results （1）Before treatment,the three groups were not significantly different in 24 hSBP,dSBP,nSBP,24 hDBP,dDBP and nDBP（ P 〉 0. 05）. After treatment,the three groups were not significantly different in 24 hSBP,dSBP,nSBP,24 hDBP,dDBP and nDBP（P 〈 0. 05）;there were significant differences between group B and group A and between group C and group A（ P 〈 0. 05）. After treatment,24 hSBP,dSBP,nSBP, 24 hDBP,dDBP,nDBP of group A and group B were significantly different from those before treatment（ P 〈 0. 05）. （2） After treatment,the proportions of patients who recovered to dipper type hypertension in group A,group B and group C were 76. 9% （40 / 52）,40. 4% （21 / 52）,5. 8% （3 / 52）,with significant differences among the three groups（χ2 = 24. 60,P 〈0. 05）,and there were significant differences in this proportion between group A and group B（ χ2 = 14. 31,P 〈 0. 05）,＆amp;nbsp;between group A and group C（ χ2 = 54. 28,P 〈 0. 05）and between B and C（ χ2 = 17. 40,P 〈 0. 05）. （3） The three groups were significantly different in efficacy（H = 41. 58,P 〈 0. 05）,and there were significant differences in efficacy between group A and group B（H = 7. 88,P 〈 0. 05）,between A and group C（H = 16. 34,P 〈 0. 05）and between group B and group C（H = 10. 72,P 〈 0. 05）. Conclusion Compared with the nighttime administration with only long - term calcium antagonist or only anti - anxiety therapy,the combined therapy is better in antihypertensive efficacy for patients with non - dipper type hypertension and anxiety disorder.
出处
《中国全科医学》
CAS
CSCD
北大核心
2015年第25期3069-3072,共4页
Chinese General Practice
关键词
非杓型高血压
钙通道阻滞药
焦虑症
时间治疗学
Non dipper type hypertension
Calcium channel blockers
Anxiety disorders
Chronotherapeutics
