摘要
目的:观察经验方养阴通脉汤对阴虚血瘀证2型糖尿病(T2DM)患者糖脂代谢的影响。方法:2011年1月~2014年10月选取84例经磺脲类药物治疗失效的T2DM患者为研究对象,根据随机数字表将T2DM患者分为观察组及对照组各42例,两组患者均行饮食干预,对照组在饮食干预基础上给餐前嚼服阿卡波糖50~100mg,3次/天。观察组在对照组基础上于饭前加服养阴通脉汤,200ml/次,3次/天,两组均持续治疗2周。对比分析两组治疗效果及不良反应发生情况。结果:观察组总有效率为90.48%,低血糖发生率为2.38%,对照组总有效率为76.19%,低血糖发生率为16.67%(P〈0.05)。观察组治疗后空腹血糖(FPG)、餐后2小时血糖(2h PG)、糖化血红蛋白(Hb A1c)、空腹胰岛素(FINS)、三酰甘油(TG)、总胆固醇(TC)、低密度蛋白(LCL-C)、C肽、餐后2小时C肽、胰岛素抵抗指数(HOMA-IR)、低于对照组(P〈0.05)。结论:养阴通脉汤与阿卡波糖均能有效改善T2DM患者胰岛抵抗,降低患者血糖,但两者联合应用可获得更理想的治疗效果。
Objective: To investigate the effects of glucose and lipid metabolism of Yangyin Tongmai Decoction combined with Acarbose on patients with T2DM. Methods : 84 cases of T2DM patients were divided into observation group ( n = 42) and controlled group (n=42) from January 2011 to December 2014. The controlled group were given with pre-dinner chew belly Acarbose, 50 - 100mg, 3 times/d. The observation group were given with Yangyin Tongmai Decoction for 2 weeks. The effects and adverse events of two groups were compared. Results : The total effective rate and hypoglycemia incidence of the observation prove insulin resistance in patients withT2DM, lower blood sugar, but their combination more desirable therapeutic effect.
出处
《四川中医》
2015年第9期53-55,共3页
Journal of Sichuan of Traditional Chinese Medicine