期刊文献+

纳米羟基磷灰石/胶原骨在骨折后骨缺损中的应用及安全性研究 被引量:2

The Application and Security Research of Nano Hydroxyapatite/Collagen Bone Defects of Bone After Fracture
下载PDF
导出
摘要 目的探究分析纳米羟基磷灰石/胶原骨材料在骨折后骨缺损中的应用及安全性。方法选取骨折后骨缺损修复患者分为试验组、对照1组、对照2组,分别采用纳米羟基磷灰石/胶原骨材料、游离自体骨和同种异体骨移植修复,对比其VAS量表情况。结果试验组患者的手术时间、术中出血量、伤口引流量及住院天数分别为(174.34±64.21)min、(266.34±125.36)ml、(142.54±98.53)ml、(12.43±4.30)d,均优于两个对照组患者(t=2.51、t=2.43、t=2.46、t=2.17,P<0.05;t=2.63、t=2.50、t=2.56、t=2.13,P<0.05),而两个对照组,组间比较以上指标[(269.32±89.51)min、(450.64±249.65)ml、(187.43±103.54)ml、(16.47±5.62)d;(194.54±77.34)min、(305.67±174.53)ml、(163.53±94.32)ml、(15.27±4.76)d],对照2组优于对照1组(t=2.32、t=2.41、t=2.57、t=2.13,P<0.05),差异具有统计学意义。三组患者术前1周VAS评分情况(8.53±1.02、8.57±1.03、8.48±1.05)无明显差异(P>0.05),试验组患者术后2周、术后4周、术后8周、术后12周VAS评分情况分别为(3.47±1.23)、(2.87±1.02)、(2.42±0.87)、(2.03±0.66),均优于对照组患者(t=2.54、t=2.53、t=2.43、t=2.40,P<0.05;t=2.36、t=2.63、t=2.49、t=2.36,P<0.05),对照2组术后2周、术后4周、术后8周、术后12周VAS评分情况分别为(4.25±1.52)、(3.11±1.03)、(2.84±1.02)、(2.51±0.83)较对照1组患者评分情况[(3.78±1.42)、(3.02±1.11)、(2.69±0.88)、(2.44±0.76)]偏优(t=2.43、t=2.13、t=2.38、t=2.10,P<0.05),具有统计学差异。结论纳米羟基磷灰石/胶原骨材料对骨折后骨缺损的修复效果较佳,安全性高,患者满意度高。 ObjectiveTo explore and analyze of nano hydroxyapatite/collagen material in the application of bone defect after fraction and its security. MethodsAll patients were randomly divided into three groups,the experimental group and the control group 1 and the control group 2, respectively using nanometer hydroxyapatite/collagen material,free autogenous bone and allograft bone graft to repair. Three groups of patients were compared with VAS scores.Results The operation time,intraoperative blood loss,wound lead flow and hospitalization days,were respectively(174.34±64.21)min,(266.34±125.36)ml,(142.54±98.53)ml,(12.43±4.30)d in the experimental group,were better than that of another two groups(t=2.51,t=2.43,t=2.46,t=2.17,P〈 0.05;t=2.63,t=2.50,t=2.56,t=2.13,P〈 0.05). And in the control group 2,al the indexes above were [(269.32±89.51)min,(450.64±249.65)ml,(187.43±103.54)ml,(16.47±5.62)d] and[(194.54±77.34) min,(305.67±174.53)ml,(163.53±94.32)ml,(15.27±4.76)d] in the control group 1,were better than that of the control group 1,(t=2.32, t=2.41,t=2.57,t=2.13,P〈 0.05),with significant difference. Three groups of patients with preoperative VAS score of 1 week were(8.53±1.02)、(8.57±1.03 )and (8.48±1.05),compared among groups with no significant difference(P〉 0.05). Patients of the experimental group in postoperative 2,4,8,12 weeks,the VAS score were respectively (3.47±1.23)、(2.87±1.02)、(2.42±0.87)、(2.03±0.66),significantly better than that of the control group(t=2.54,t=2.53,t=2.43,t=2.40,P〈 0.05;t=2.36,t=2.63,t=2.49,t=2.36,P〈 0.05). Patients of the group 2 in postoperative 2,4,8,12 weeks,the VAS score were respectively(4.25±1.52),(3.11±1.03),(2.84±1.02),(2.51±0.83), noticeably superior than that of the control group 1 for grading [(3.78±1.42),(3.02±1.11),(2.69±0.88),(2.44±0.76)], compared with statistical difference(t=2.43,t=2.13,t=2.38,t=2.10,P〈 0.05).Conclusion Nano hydroxyapatite/colagen bone material of fracture bone defect repair has remarkable effect ,wide security and high patient satisfaction.
作者 张丽艳
机构地区 东营鸿港医院
出处 《中国卫生标准管理》 2015年第24期85-88,共4页 China Health Standard Management
关键词 网纳米羟基磷灰石 骨折 骨缺损 安全性 Net nanometer hydroxyapatite Fracture Bone defect Security
  • 相关文献

参考文献10

二级参考文献200

共引文献173

同被引文献37

引证文献2

二级引证文献18

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部